3F8
Tocris Bioscience, part of Bio-Techne | Catalog # 4083
Potent and selective GSK-3β inhibitor
Discontinued Product
4083 has been discontinued.
View all GSK-3 Inhibitors products.
Product Description
3F8 is a potent and selective GSK-3β inhibitor (IC50 values are 34 and 304 nM in the presence of 10 and 100 μM ATP respectively).Product Specifications
Molecular Weight
286.28
Formula
C15H14N2O4
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]isoquinoline-1,3(2H)-dione
CAS Number
159109-11-2
PubChem ID
23829003
InChI Key
ULVWJFBHQIXEPE-UHFFFAOYSA-N
SMILES
O=C(NC3=O)C2=C3C1=CC(OC)=C(OC)C=C1C(CC)=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.16 | 25 |
Preparing Stock Solutions
for 3F8
The following data is based on the product molecular weight 286.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 13.97 mL | 69.86 mL | 139.72 mL |
| 1.25 mM | 2.79 mL | 13.97 mL | 27.94 mL |
| 2.5 mM | 1.40 mL | 6.99 mL | 13.97 mL |
| 12.5 mM | 0.28 mL | 1.40 mL | 2.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zou Benzo[e]isoindole-1,3-diones as potential inhibitors of glycogen synthase kinase-3 (GSK-3). Synthesis, kinase inhibitory activity, zebrafish phenotype, and modeling of binding mode. J.Med.Chem. 2010 PMID: 20030405
- Zhong Characterization and development of novel small-molecules inhibiting GSK3 and activating wnt signaling. Mol.Biosyst. 2009 PMID: 19823752
Product Specific Notices for 3F8
For research use only
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