3',3'-cGAMP sodium salt

Tocris Bioscience, part of Bio-Techne | Catalog # 5946

STING agonist
Discontinued Product
5946 has been discontinued.

Key Product Details

Description

STING agonist

Product Description

3',3'-cGAMP sodium salt is a STING agonist. Reduces B cell proliferation and induces apoptosis of malignant B cells in vitro. Suppresses 5TGM1 multiple myeloma xenograft growth in immunodeficient mice, and induces leukemic regression in Eμ-TCL1 mice.

This product is sold in units of 359μg, equivalent to 0.5μmol.

Product Specifications

Molecular Weight

718.37

Formula

C20H22N10Na2O13P2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt

CAS Number

2407516-83-8

PubChem ID

121513907

InChI Key

MFPHQIYDBUVTRL-DQNSRKNCSA-L

SMILES

[H][C@@]12COP(O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O[C@@]1([H])[C@@H](O)[C@@H](O2)N4C=NC5=C4N=C(NC5=O)N)(O[Na])=O)N6C=NC7=C(N)N=CN=C67)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.18 10

Preparing Stock Solutions for 3',3'-cGAMP sodium salt

The following data is based on the product molecular weight 718.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.92 mL 69.60 mL 139.20 mL
0.5 mM 2.78 mL 13.92 mL 27.84 mL
1 mM 1.39 mL 6.96 mL 13.92 mL
5 mM 0.28 mL 1.39 mL 2.78 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for 3',3'-cGAMP sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 3',3'-cGAMP sodium salt

For research use only

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