2-Methyl-5-hydroxytryptamine hydrochloride

Name: 2-Methyl-5-hydroxytryptamine hydrochloride
Brand: tocris
SKU: 0558

Catalog # 0558

Datasheet / COA / SDS

Discontinued Product

0558 has been discontinued. View all 5-HT3 Receptor Agonists products.

Order Information

Bio-Techne Corporation

tel: (612) 379-2956

tel: (800) 343-7475 (free phone)

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	5-HT₃ agonist/potent 5-HT₆ ligand
Purity:	≥98% (HPLC)

View Full Technical Details for 2-Methyl-5-hydroxytryptamine hydrochloride

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Biological Activity

5-HT₃ agonist (K_i = 1200 nM) and potent 5-HT₆ ligand (K_i = 46 nM).

Technical Data

M. Wt	226.71
Formula	C₁₁H₁₄N₂O.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	845861-49-6
PubChem ID	11492320
InChi Key	ZNVRHQPXSBWLQP-UHFFFAOYSA-N
Smiles	Cl.CC1=C(CCN)C2=CC(O)=CC=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	22.67	100

Preparing Stock Solutions

The following data is based on the product molecular weight 226.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.41 mL	22.05 mL	44.11 mL
5 mM	0.88 mL	4.41 mL	8.82 mL
10 mM	0.44 mL	2.21 mL	4.41 mL
50 mM	0.09 mL	0.44 mL	0.88 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Craig 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT₃ and putative 5-HT₄ receptors in guinea pig ileum. Naunyn Schmiedebergs Arch.Pharmacol. 1990 PMID: 2402303
Glennon 2-substituted tryptamines: agents with selectivity for 5-HT₆ serotonin receptors. J.Med.Chem. 2000 PMID: 10715164
Ismaiel 5-HT₁ and 5-HT₂ binding profiles of the serotonergic agents α-methyl serotonin and 2-methylserotonin. J.Med.Chem. 1990 PMID: 2299641
Wilson 5-Hydroxytryptamine₃ receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 1990 PMID: 1968974

Citations

Currently there are no citations for 2-Methyl-5-hydroxytryptamine hydrochloride.