2-Methoxyestradiol

Name: 2-Methoxyestradiol
Brand: Tocris Bioscience
SKU: 1807

Tocris Bioscience, part of Bio-Techne | Catalog # 1807

Citations (8)

COA / SDS

Apoptotic and antiangiogenic agent

Discontinued Product

1807 has been discontinued. View all Apoptosis Inducer Compounds products.

Key Product Details

Description:	Apoptotic and antiangiogenic agent
Chemical Name:	(17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
Purity:	≥99% (HPLC)
Molecular Weight:	302.41

View Full Technical Details for 2-Methoxyestradiol

Technical Data
Citations

Biological Activity for 2-Methoxyestradiol

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

Technical Data for 2-Methoxyestradiol

M. Wt	302.41
Formula	C₁₉H₂₆O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	362-07-2
PubChem ID	66414
InChi Key	CQOQDQWUFQDJMK-SSTWWWIQSA-N
Smiles	OC1=C(OC)C=C2C(CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for 2-Methoxyestradiol

References are publications that support the biological activity of the product.

Shimada Roles of p38 and c-jun NH₂-terminal kinase-mediated pathways in 2-methoxyOE-induced p53 induction and apoptosis. Carcinogenesis 2003 PMID: 12807754
LaVallee 2-MethoxyOE inhibits proliferation and induces apoptosis independently of estrogen receptors α and β. Cancer Res. 2002 PMID: 12097276
LaVallee 2-MethoxyOE up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 2003 PMID: 12543804
D'Amato 2-MethoxyOE, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colch. site. Proc.Natl.Acad.Sci.U.S.A. 1994 PMID: 8171020

2-Methoxyestradiol

Tocris Bioscience, part of Bio-Techne | Catalog # 1807

Key Product Details

Biological Activity for 2-Methoxyestradiol

Technical Data for 2-Methoxyestradiol

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for 2-Methoxyestradiol

Product Documents for 2-Methoxyestradiol

COA

Certificate of Analysis

SDS

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