2-Methoxyestradiol

Name: 2-Methoxyestradiol
Brand: Tocris Bioscience
SKU: 1807

Tocris Bioscience a Bio-Techne Brand

Catalog # 1807

Citations (1)

COA / SDS

Discontinued Product

1807 has been discontinued. View all Apoptosis Inducer Compounds products.

Key Product Details

Description:	Apoptotic and antiangiogenic agent
Chemical Name:	(17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
Purity:	≥99% (HPLC)
Molecular Weight:	302.41

View Full Technical Details for 2-Methoxyestradiol

Biological Activity for 2-Methoxyestradiol

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

Technical Data for 2-Methoxyestradiol

M. Wt	302.41
Formula	C₁₉H₂₆O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	362-07-2
PubChem ID	66414
InChi Key	CQOQDQWUFQDJMK-SSTWWWIQSA-N
Smiles	OC1=C(OC)C=C2C(CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Methoxyestradiol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	15.12	50

Preparing Stock Solutions for 2-Methoxyestradiol

The following data is based on the product molecular weight 302.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.61 mL	33.07 mL	66.14 mL
2.5 mM	1.32 mL	6.61 mL	13.23 mL
5 mM	0.66 mL	3.31 mL	6.61 mL
25 mM	0.13 mL	0.66 mL	1.32 mL

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Reconstitution Calculator

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References for 2-Methoxyestradiol

References are publications that support the biological activity of the product.

LaVallee 2-MethoxyOE up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 2003 PMID: 12543804
Shimada Roles of p38 and c-jun NH₂-terminal kinase-mediated pathways in 2-methoxyOE-induced p53 induction and apoptosis. Carcinogenesis 2003 PMID: 12807754
LaVallee 2-MethoxyOE inhibits proliferation and induces apoptosis independently of estrogen receptors α and β. Cancer Res. 2002 PMID: 12097276
D'Amato 2-MethoxyOE, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colch. site. Proc.Natl.Acad.Sci.U.S.A. 1994 PMID: 8171020

Citations for 2-Methoxyestradiol (1)

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Citations are publications that use Bio-Techne products. Selected citations for 2-Methoxyestradiol include:

Valencia-Cervantes et al. (2019) Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia-inducible factor 1α-mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation. Oncol Rep. 41:178
PMID: 30320358

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