2-Iodomelatonin

Name: 2-Iodomelatonin
Brand: Tocris Bioscience
SKU: 0737

Tocris Bioscience a Bio-Techne Brand

Catalog # 0737

Citations (5)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	High affinity melatonin agonist
Chemical Name:	N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	358.18

View Full Technical Details for 2-Iodomelatonin

Biological Activity for 2-Iodomelatonin

2-Iodomelatonin is a potent melatonin agonist (pK_i values are 10.55 and 9.87 at human recombinant MT₁ and MT₂ receptors respectively). 2-[¹²⁵I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

Technical Data for 2-Iodomelatonin

M. Wt	358.18
Formula	C₁₃H₁₅IN₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	93515-00-5
PubChem ID	115348
InChi Key	FJDDSMSDZHURBJ-UHFFFAOYSA-N
Smiles	COC1=CC=C2NC(I)=C(CCNC(C)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Iodomelatonin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.82	100
	ethanol	35.82	100

Preparing Stock Solutions for 2-Iodomelatonin

The following data is based on the product molecular weight 358.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.96 mL	27.92 mL
5 mM	0.56 mL	2.79 mL	5.58 mL
10 mM	0.28 mL	1.40 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 2-Iodomelatonin

References are publications that support the biological activity of the product.

Browning Pharmacological characterization of human recombinant melatonin mt₁ and MT₂ receptors. Br.J.Pharmacol. 2000 PMID: 10696085
Suiciak Quantitative pharmacological analysis of 2-[¹²⁵l]-iodomelatonin binding sites in discrete areas of the chicken brain. J.Neurosci. 1991 PMID: 1652626
Dubocovich and Takahashi Use of 2-[¹²⁵l]-iodomelatonin to characterize melatonin sites in chicken retina. Proc.Natl.Acad.Sci.U.S.A. 1987 PMID: 3035559

Citations for 2-Iodomelatonin (5)

Showing 1 - 5 of 5 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for 2-Iodomelatonin include:

Stauch et al. (2019) Structural basis of ligand recognition at the human MT1 melatonin receptor Nature. 569:284
PMID: 31019306
Akoume et al. (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep. 9:10074
PMID: 31296888
Hou et al. (2017) Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci. 11:98
PMID: 28473754
Calamini et al. (2008) Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J. 413:81
PMID: 18254726
Nosjean et al. (2000) Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem. 275:31311
PMID: 10913150

There are no citations that match your criteria.