(1R,1'S,3'R/1R,1'R,3'S)-L-054,264

Name: (1 R ,1' S ,3' R /1 R ,1' R ,3' S )-L-054,264
Brand: Tocris Bioscience
SKU: 2444

Catalog # 2444 | Tocris Bioscience a Bio-Techne Brand

COA / SDS

Potent and selective sst2 agonist

Key Product Details

Description:	Potent and selective sst₂ agonist
Chemical Name:	N-[(1R)-2-[[[(1S,3R)-3-(Aminomethyl)cyclohexyl]methyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxoethyl]spiro[1H-indene-1,4'-piperidine]-1'-carboxamide
Purity:	≥96% (HPLC)
Molecular Weight:	539.71

View Full Technical Details for (1R,1'S,3'R/1R,1'R,3'S)-L-054,264

Technical Data
Citations / Reviews

Biological Activity

(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a potent and selective somatostatin sst₂ receptor agonist (K_i values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst₂, sst₁, sst₄, sst₃ and sst₅ receptors respectively).

Technical Data

M. Wt	539.71
Formula	C₃₃H₄₁N₅O₂
Storage	Store at +4°C
Purity	≥96% (HPLC)
CAS Number	208706-12-1
PubChem ID	9915239
InChi Key	DAMXHAMKVXERLM-FVBCXUTKSA-N
Smiles	NC[C@H]1CCC[C@@H](CNC([C@H](NC(N4CCC5(C(C=CC=C6)=C6C=C5)CC4)=O)CC2=CNC3=C2C=CC=C3)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.99	50
	ethanol	53.97	100

Preparing Stock Solutions

The following data is based on the product molecular weight 539.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.26 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL
10 mM	0.19 mL	0.93 mL	1.85 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Yang Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst₂) agonists. J.Med.Chem. 1998 PMID: 9632348

Citations for (1R,1'S,3'R/1R,1'R,3'S)-L-054,264

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