1-Methylpsilocin

Name: 1-Methylpsilocin
Brand: Tocris Bioscience
SKU: 3017

Tocris Bioscience a Bio-Techne Brand

Catalog # 3017

Citations (1)

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Key Product Details

Description:	Potent and selective 5-HT_2C agonist
Chemical Name:	3-[2-(Dimethylamino)ethyl]-1-methylindol-4-ol
Purity:	≥99% (HPLC)
Molecular Weight:	218.29

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Biological Activity for 1-Methylpsilocin

1-Methylpsilocin is a potent and selective 5-HT_2C agonist (IC₅₀ values are 12 and 633 nM for 5-HT_2C and 5-HT_2A receptors respectively). Displays high affinity for the 5-HT_2B receptor (K_i = 38 nM) but acts as an inverse agonist. Active in vivo; inhibits scratching in a mouse model of OCD.

Technical Data for 1-Methylpsilocin

M. Wt	218.29
Formula	C₁₃H₁₈N₂O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1465-16-3
PubChem ID	44404883
InChi Key	MZZRFEIDRWKTKJ-UHFFFAOYSA-N
Smiles	OC1=C2C(N(C)C=C2CCN(C)C)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 1-Methylpsilocin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	21.83	100
	ethanol	2.18	10

Preparing Stock Solutions for 1-Methylpsilocin

The following data is based on the product molecular weight 218.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.58 mL	22.91 mL	45.81 mL
5 mM	0.92 mL	4.58 mL	9.16 mL
10 mM	0.46 mL	2.29 mL	4.58 mL
50 mM	0.09 mL	0.46 mL	0.92 mL

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References for 1-Methylpsilocin

References are publications that support the biological activity of the product.

Sard SAR of psilocybin analogs: discovery of a selective 5-HT_2C agonist. Bioorg.Med.Chem.Letts.

Citations for 1-Methylpsilocin (1)

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Citations are publications that use Bio-Techne products. Selected citations for 1-Methylpsilocin include:

Halberstadt et al. (2011) Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice. J.Psychopharmacol.. 25:1548
PMID: 21148021

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