MNITMT
Tocris Bioscience, part of Bio-Techne | Catalog # 2492
Novel, non-toxic immunosuppressive agent
Discontinued Product
2492 has been discontinued.
View all Immunosuppressants products.
Key Product Details
Description
Novel, non-toxic immunosuppressive agent
Alternative Names
NSC 631156
Product Description
MNITMT is a novel, non-toxic immunosuppressive agent. Inhibits human mixed lymphocyte reaction in vitro (ED50 = 2.7 μM) and prolongs skin graft survival in mice. Produces a 98.1% reduction in antibody response following oral administration in rabbits.Previously sold as Cat. No. 0564.
Product Specifications
Molecular Weight
240.24
Formula
C7H8N6O2S
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
4-Methyl-3-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-4H-1,2,4-triazole
CAS Number
177653-76-8
PubChem ID
364622
InChI Key
NMBDIMPYACLUDE-UHFFFAOYSA-N
SMILES
CN1C=NN=C1SC1=C(N=CN1C)[N+]([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.4 | 10 |
Preparing Stock Solutions
for MNITMT
The following data is based on the product molecular weight 240.24
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 41.63 mL | 208.13 mL | 416.25 mL |
| 0.5 mM | 8.33 mL | 41.63 mL | 83.25 mL |
| 1 mM | 4.16 mL | 20.81 mL | 41.63 mL |
| 5 mM | 0.83 mL | 4.16 mL | 8.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Al-Safi Comparison of the effects of azathio. and its novel non-mercaptopurine analog on antibody response in rabbits. Pol.J.Pharmacol. 2003 PMID: 12926553
- Crawford Rational design of novel immunosuppressive drugs: analogues of azathio. lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects. J.Med.Chem. 1996 PMID: 8709098
Product Specific Notices for MNITMT
For research use only
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