Simple Plex Control for Human CCL5/RANTES

Name: Simple Plex Control for Human CCL5/RANTES
Brand: ProteinSimple
SKU: 898278

ProteinSimple, part of Bio-Techne | Catalog # 898278

Product Datasheet / COA

Control for use with Human and Non-Human Primate CCL5/RANTES Simple Plex Cartridge Kit

Key Product Details

Technical Data
Citations

Summary for Simple Plex Control for Human CCL5/RANTES

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human and NHP CCL5/RANTES concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.

CCL5/RANTES is a secreted beta-chemokine that plays a primary role in the inflammatory immune response through chemoattraction and activation of leukocytes that express CCR1, 3, 4, or 5. The two N-terminal residues of CCL5 can be removed by CD26/DPPIV, generating a protein that functions as a chemotaxis inhibitor. The deposition of CCL5 on activated vascular endothelial cells is crucial for monocyte adhesion to damaged vasculature. CCL5 is upregulated in breast cancer and promotes tumor progression through the attraction of proinflammatory macrophages in addition to its actions on tumor cells, stromal cells, and the vasculature. In humans, CCR5 binding to CCL5 inhibits the infectivity of R5 (M-tropic) but not X4 (T-tropic) strains of HIV-1.

Product Specifications for Simple Plex Control for Human CCL5/RANTES

Species	Human, Non-human Primate
Applications	Control, Simple Plex Automated Immunoassay
Source	N/A

Preparation & Storage

Shipping Conditions

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage

• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.

Background: CCL5/RANTES

Item	Value
Entrez Gene IDs	6352 (Human); 20304 (Mouse); 403522 (Canine); 493689 (Feline)
Alternate Names	CCL5, D17S136Enormally T-expressed, and presumably secreted, EoCP, Eosinophil chemotactic cytokine, RANTES, SIS-delta, SISd, Small-inducible cytokine A5, T cell-specific protein P228, T-cell specific protein p288, TCP228T-cell-specific protein RANTES, chemokine (C-C motif) ligand 5, small inducible cytokine A5 (RANTES), small inducible cytokine subfamily A (Cys-Cys), member 5

Product Documents for Simple Plex Control for Human CCL5/RANTES

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