Recombinant Human IGSF9B Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 9248-S9

R&D Systems, part of Bio-Techne
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9248-S9-050
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Key Product Details

Source

HEK293

Accession #

Q9UPX0

Conjugate

Unconjugated

Applications

Bioactivity

View all IGSF9B Proteins and Enzymes »

Product Specifications

Source

Human embryonic kidney cell, HEK293-derived human IGSF9B protein
Glu21-Pro722, with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Glu21

Predicted Molecular Mass

79 kDa

SDS-PAGE

83-107 kDa, reducing conditions

Activity

Bioassay data are not available.

Formulation, Preparation and Storage

9248-S9
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution
Reconstitute at 500 μg/mL in PBS.

Reconstitution Buffer Available:
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Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IGSF9B

IGSF9B, is an approximately 190 kDa transmembrane glycoprotein that plays a role in neuronal synapse maintenance and function (1). Mature human IGSF9B consists of a 702 amino acid (aa) extracellular domain (ECD) with 5 Ig-like domains and 2 fibronectin type-3 domains, a 21 aa transmembrane segment, and a 606 aa cytoplasmic domain. Within the ECD, human IGSF9B shares 97% aa sequence identity with mouse and rat IGSF9B. IGSF9B is widely expressed on interneurons in the brain where it localizes to inhibitory synapses in a ternary complex with Neuroligin-2 and S-SCAM (2). IGSF9B functions as a homophilic adhesion molecule and is required for the maturation of inhibitory synapses on interneurons (2). It shares 37% aa sequence identity with human IGSF9/Dasm1 which is expressed in the brain and dorsal root and trigeminal ganglia (3-6). Dasm1 also functions as a homophilic adhesion protein that supports the maintenance of inhibitory synapses as well as inhibitory neurotransmission (6, 7).

References

  1. Hansen, M. and P.S. Walmod (2013) Neurochem. Res. 38:1236.
  2. Woo, J. et al. (2013) J. Cell Biol. 201:929.
  3. Doudney, K. et al. (2002) Genomics 79:663.
  4. Shi, S.-H. et al. (2004) Proc. Natl. Acad. Sci. USA 101:13341.
  5. Mishra, A. et al. (2008) Mol. Cell. Biol. 28:2782.
  6. Mishra, A. et al. (2014) J. Neurosci. 34:4187.
  7. Shi, S.-H. et al. (2004) Proc. Natl. Acad. Sci. USA 101:13346.

Long Name

Immunoglobulin Superfamily, Member 9B

Alternate Names

immunoglobulin superfamily, member 9B

Entrez Gene IDs

22997 (Human); 235086 (Mouse); 315510 (Rat)

Gene Symbol

IGSF9B

UniProt

Q9UPX0

Additional IGSF9B Products

Product Documents for Recombinant Human IGSF9B Protein, CF

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human IGSF9B Protein, CF

For research use only

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