Recombinant Human BMP-9 Protein
R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Source: | CHO |
Accession #: | Q9UK05 |
Structure / Form: | Disulfide-linked homodimer |
Applications: | Bioactivity |
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Citations for Recombinant Human BMP-9 Protein (47)
Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human BMP-9 Protein include:
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Species: Human
Sample Types: Whole Cells
Applications: Cell CultureC Ivaldo et al. (2023), Oxidative stress-induced MMP- and gamma-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10 Scientific Reports, 13(1):597.
PMID: 36631513 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureF Kawecki et al. (2022), Preclinical Evaluation of BMP-9-Treated Human Bone-like Substitutes for Alveolar Ridge Preservation following Tooth Extraction International Journal of Molecular Sciences, 23(6).
PMID: 35328724 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Addante et al. (2022), BMP9 Promotes an Epithelial Phenotype and a Hepatocyte-like Gene Expression Profile in Adult Hepatic Progenitor Cells Cells, 11(3).
PMID: 35159174 -
Species: Human
Sample Types: Organoid
Applications: BioassayDL Marvin et al. (2022), Dynamic Visualization of TGF-beta/SMAD3 Transcriptional Responses in Single Living Cells Cancers, 14(10).
PMID: 35626109 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZ Shonibare et al. (2022), Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer Oncogene, 40(4):111066.
PMID: 35905726 -
Species: Mouse
Sample Types: In Vivo
Applications: BioassayM Fujioka-Ko et al. (2021), Osteoinductive potential of recombinant BMP-9 in bone defects of mice treated with antiresorptive agents International journal of oral and maxillofacial surgery, 0(0).
PMID: 34454793 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayQ Jiang et al. (2021), BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-&kapppaB dependent macrophage polarization International immunopharmacology, 96(0):107591.
PMID: 33812253 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureX Wang et al. (2020), CD105 overexpression mediates drug-resistance in choriocarcinoma cells through BMP9/Smad pathway J Cancer, 11(2):272-283.
PMID: 31897223 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Alinejad et al. (2020), Both Human Hematoma Punctured from Pelvic Fractures and Serum Increase Muscle Resident Stem Cells Response to BMP9: A Multivariate Statistical Approach J Clin Med, 9(4).
PMID: 32325892 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureA Addante et al. (2020), A Signaling Crosstalk between BMP9 and HGF/c-Met Regulates Mouse Adult Liver Progenitor Cell Survival Cells, 9(3).
PMID: 32204446 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayB Tao et al. (2020), BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells J Biol Chem, 0(0).
PMID: 33097593 -
Species: Mouse
Sample Types: Beads
Applications: In VivoL Yu et al. (2019), BMP9 stimulates joint regeneration at digit amputation wounds in mice Nat Commun, 10(1):424.
PMID: 30723209 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayG Drouin et al. (2019), Muscle injury-induced hypoxia alters the proliferation and differentiation potentials of muscle resident stromal cells Skelet Muscle, 9(1):18.
PMID: 31217019 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Cao et al. (2019), Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives Stem Cell Reports, 12(6):1282-1297.
PMID: 31189095 -
Applications: Western BlotE Tillet et al. (2018), A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma J. Biol. Chem., 0(0).
PMID: 29789425 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayK Schlereth et al. (2018), The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium Elife, 7(0).
PMID: 29749927 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayM Subileau et al. (2018), Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation Stem Cell Reports, 0(0).
PMID: 30595547 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Tian et al. (2018), Endoglin interacts with VEGFR2 to promote angiogenesis FASEB J., 0(0):fj201700867RR.
PMID: 29401587 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Akatsu et al. (2017), Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis Cancer Sci, 108(1):151-155.
PMID: 28133920 -
Species: Rat
Sample Types: In Vivo
Applications: In VivoW Abdullahi et al. (2017), Bone morphogenetic protein-9 increases the functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier via the activin receptor-like kinase-1 receptor J. Cereb. Blood Flow Metab., 0(0):271678X177029.
PMID: 28387157 -
Applications: ELISA (Standard)K Breitkopf- et al. (2017), BMP-9 interferes with liver regeneration and promotes liver fibrosis Gut, 0(0).
PMID: 28336518 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCG Mitrofan et al. (2017), Bone morphogenetic protein (BMP) 9 and BMP10 enhance tumor necrosis factor-?-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2 J. Biol. Chem., 0(0).
PMID: 28646109 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayK Sakamoto et al. (2017), Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology Biochem Biophys Rep, 11(0):33-39.
PMID: 28955765 -
Species: Mouse
Sample Types: Whole Tissue
Applications: BioassaySR Pasricha et al. (2017), Hepcidin is regulated by promoter-associated histone acetylation and HDAC3 Nat Commun, 8(1):403.
PMID: 28864822 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMA Lauzon et al. (2017), Peptides derived from the knuckle epitope of BMP-9 induce the cholinergic differentiation and inactivate GSk3beta in human SH-SY5Y neuroblastoma cells Sci Rep, 7(1):4695.
PMID: 28680159 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Tachida et al. (2017), Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells Biol Open, 6(3):370-380.
PMID: 28298363 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016), MxA Is a Novel Regulator of Endosome-Associated Transcriptional Signaling by Bone Morphogenetic Proteins 4 and 9 (BMP4 and BMP9) PLoS ONE, 11(11):e0166382.
PMID: 27875556 -
Species: Human
Sample Types: Recombinant Protein
Applications: Enzyme AssayKraehling J et al. (2016), Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nat Commun, 7(0):13516.
PMID: 27869117 -
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay(2016), Hyaluronic Acid Gel-Based Scaffolds as Potential Carrier for Growth Factors: An In Vitro Bioassay on Its Osteogenic Potential J Clin Med, 5(12).
PMID: 27916889 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016), Bone Morphogenetic Protein 9 Enhances Lipopolysaccharide-Induced Leukocyte Recruitment to the Vascular Endothelium J Immunol, 0(0).
PMID: 27647829 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLevet S et al. (2015), BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A, 112(25):E3207-15.
PMID: 26056270 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayYoung K et al. (2015), BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses. PLoS ONE, 10(4):e0122892.
PMID: 25909848 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTate C et al. (2015), A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology. PLoS ONE, 10(4):e0125697.
PMID: 25919028 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWoltje K et al. (2015), Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS ONE, 10(3):e0120547.
PMID: 25799559 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayPan C et al. (2014), Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis. J Biol Chem, 289(37):25486-96.
PMID: 25070888 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayOlsen O et al. (2014), Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J, 4(0):e196.
PMID: 24658374 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLiu Y et al. (2013), Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nat Biotechnol, 31(5):440-7.
PMID: 23604284 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2012), BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood, 119(25):6162-71.
PMID: 22566602 -
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon ResonanceWu et al. (2012), Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE, 7(9):e46307.
PMID: 23029472 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilson TR et al. (2012), Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 487(7408):505-9.
PMID: 22763448 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayYoung et al. (2012), BMP9 regulates endoglin-dependent chemokine responses in endothelial cells. Blood, 120(20):4263-73.
PMID: 23018639 -
Species: Human
Sample Types: Cell Lysates
Applications: BioassayYao Y et al. (2012), Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood, 119(21):5037-47.
PMID: 22474252 -
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon ResonanceCastonguay R et al. (2011), Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 286(34):30034-46.
PMID: 21737454 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRicard N et al. (2010), Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations. Blood, 116(9):1604-12.
PMID: 20501893 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayHerrera B et al. (2009), A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol., 10(0):20.
PMID: 19298647 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDavid L et al. (2007), Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood, 109(5):1953-61.
PMID: 17068149 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayLin L et al. (2007), Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood, 110(6):2182-9.
PMID: 17540841
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Customer Reviews for Recombinant Human BMP-9 Protein (2)
Customer Images
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Application: In vitro bioactivity in cell cultureVerified Customer | Posted 11/20/2019Stimulated cell line with BMP-9 protein to induce pSmad 1/5/8 signaling
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Application: CellProlifReason for Rating: This product exceeded expectations and produced beautiful data from my experiment. I have already purchased more vials.Verified Customer | Posted 10/09/2019
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FAQs for Recombinant Human BMP-9 Protein
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What is the half-life of a recombinant or natural protein in culture at 37 °C?
R&D Systems has not determined the half-life of recombinant or natural proteins in culture. For cell-based bioassays, the incubation period of the protein with the cells typically ranges from 48 to 96 hours. Assay conditions for each protein will need to be optimized by each researcher.