VU 0364770
Tocris Bioscience, part of Bio-Techne | Catalog # 4469
Positive allosteric modulator of mGlu4 receptors
Discontinued Product
4469 has been discontinued.
View all Group III mGluR Modulators products.
Key Product Details
Description
Positive allosteric modulator of mGlu4 receptors
Product Description
VU 0364770 is a positive allosteric modulator at mGlu4 receptors (EC50 = 290 nM in mGlu4-expressing HEK 293 cells). Reverses haloperidol-induced catalepsy in rats; prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Exhibits affinity for MAO-B and MAO-A (Ki values are 0.72 μM and 8.5 μM respectively). Brain penetrant.Product Specifications
Molecular Weight
232.67
Formula
C12H9ClN2O
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
N-(3-Chlorophenyl)-2-pyridinecarboxamide
CAS Number
61350-00-3
PubChem ID
836002
InChI Key
SUYUTNCKIOLMAJ-UHFFFAOYSA-N
SMILES
O=C(C2=NC=CC=C2)NC1=CC=CC(Cl)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.27 | 100 |
Preparing Stock Solutions
for VU 0364770
The following data is based on the product molecular weight 232.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.30 mL | 21.49 mL | 42.98 mL |
| 5 mM | 0.86 mL | 4.30 mL | 8.60 mL |
| 10 mM | 0.43 mL | 2.15 mL | 4.30 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.86 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for VU 0364770
For research use only
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