GTS 21 dihydrochloride

Product Description

GTS 21 dihydrochloride is a partial agonist of α7 nicotinic acetylcholine receptors (nAChRs); also a weak α4β2 and 5-HT₃ antagonist at micromolar concentrations. Exhibits improved sensory inhibition in DBA/2 mice following both acute and chronic administration. Also shown to improve memory in several animal models; facilitates hippocampal long-term potentiation. Also has anti-inflammatory effects independent of α7 nAChRs.

Solubility

Preparing Stock Solutions for GTS 21 dihydrochloride

The following data is based on the product molecular weight 381.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.25 mL	26.23 mL	52.45 mL
2.5 mM	1.05 mL	5.25 mL	10.49 mL
5 mM	0.52 mL	2.62 mL	5.25 mL
25 mM	0.10 mL	0.52 mL	1.05 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Garg and Loring GTS-21 has cell-specific anti-inflammatory effects independent of a7 nicotinic acetylcholine receptors. PLoS One 2019 PMID: 30947238
• Meyer Effects of anabaseine-related analogs on rat brain nicotinic receptor binding and on avoidance behaviors. Drug Dev.Res.
• Olincy Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the a7 nicotinic receptor. Handb.Exp.Pharmacol. 2012 PMID: 23027417
• Stevens Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice. Brain.Res. 2010 PMID: 20599427