AMG 548
Tocris Bioscience, part of Bio-Techne | Catalog # 3920
Potent and selective p38α inhibitor
Discontinued Product
3920 has been discontinued.
View all p38 Inhibitors products.
Product Description
AMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis.Product Specifications
Molecular Weight
461.56
Formula
C29H27N5O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone
CAS Number
864249-60-5
PubChem ID
11167112
InChI Key
RQVKVJIRFKVPBF-VWLOTQADSA-N
SMILES
O=C1N(C)C(NC[C@@H](N)CC5=CC=CC=C5)=NC(C4=CC=NC=C4)=C1C3=CC2=C(C=C3)C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.8 | 100 | |
| Ethanol | 49.8 | 100 |
Preparing Stock Solutions
for AMG 548
The following data is based on the product molecular weight 461.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.17 mL | 10.83 mL | 21.67 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.33 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.17 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lee and Dominguez MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein. Curr.Med.Chem. 2005 PMID: 16378500
- Dominguez p38 MAP kinase inhibitors: many are made, but few are chosen. Curr.Opin.Drug Discov.Devel. 2005 PMID: 16022178
Product Specific Notices for AMG 548
For research use only
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