Ischemin sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 4695
CBP inhibitor; cell permeable
Discontinued Product
4695 has been discontinued.
View all Bromodomain Inhibitors products.
Product Description
Ischemin sodium salt is a CBP bromodomain inhibitor. Inhibits p53 interaction with CBP and decreases p53 transcriptional activity. Protects against Doxorubicin-induced apoptosis in cardiomyocytes in vitro. Cell permeable.Product Specifications
Molecular Weight
357.36
Formula
C15H16N3O4SNa
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid sodium salt
PubChem ID
64983
InChI Key
XWNMORIHKRROGW-UHFFFAOYSA-N
SMILES
CC1=CC(/N=N/C2=C(C)C=C(C)C(S(=O)(O[Na])=O)=C2)=C(N)C=C1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 35.74 | 100 | |
| DMSO | 35.74 | 100 |
Preparing Stock Solutions
for Ischemin sodium salt
The following data is based on the product molecular weight 357.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.80 mL | 13.99 mL | 27.98 mL |
| 5 mM | 0.56 mL | 2.80 mL | 5.60 mL |
| 10 mM | 0.28 mL | 1.40 mL | 2.80 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Borah A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem.Biol. 2011 PMID: 21513889
Product Specific Notices for Ischemin sodium salt
For research use only
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