Maurice CE-SDS and icIEF Instrument

Name: Maurice
Brand: ProteinSimple
SKU: 090-000

ProteinSimple, part of Bio-Techne | Catalog # 090-000

Product Documents

Your workhorse station for purity, identity and heterogeneity analysis

Maurice innovates the conventional capillary electrophoresis technology to automate your protein profiling either by size or charge. Need cIEF and CE-SDS data for your mAbs, ADCs, vaccines or virus-like particles? Maurice does it all. Just pop in one of the preassembled cartridges, drop in your sample vials or a 96-well plate, and hit start. You'll complete your method development in a day and get high-resolution, reproducible data in minutes. Get compliant data with either Compass for iCE or Waters Empower software.

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Purity, identity and heterogeneity

Still spending weeks or months on method development for your biologics? This new advanced CE platform lets you easily switch between cIEF and CE-SDS applications and develop platform methods within a day. In this short video, the people behind the gold-standard iCE technology highlight the key benefits of the new platform for CE analysts. Find out how Maurice makes CE easy with his streamlined workflow and delivers identity, purity and heterogeneity data on your biologics fast.

Available Services

_{*Not all service plans are available in all countries.}

Platinum At Purchase**
Platinum - All-inclusive package where we minimize instrument downtime by offering our highest priority response time and a ready supply of parts.
Gold - Enhanced coverage, including repair time, annual maintenance, fewer workflow disruptions, and optimized laboratory productivity.
Silver - To protect your lab with annual on-site maintenance, technical support, and software updates.

^{**Available only at the time of instrument purchase, Platinum At Purchase is a 12-month platinum-level service plan (unlimited on-site service, one preventative maintenance visit with required materials, and full coverage of repair parts, labor, and travel with 1st tier response) effective after the initial 12-month warranty. Includes a complimentary upgrade of the initial 12-month warranty to platinum-level (1st tier response) and two, four-year FAS tokens. Tokens must be combined to redeem one refresher or advanced training session for the purchased system, contingent on maintaining platinum-level coverage. Subject to Standard Service Terms and Conditions attached to Quote.}

About Maurice
Citations / Testimonials (6)

How Can Maurice Help You?

	My molecule has complicated charge profiles that are difficult to resolve Maurice affords high-resolution characterization of charge variants by preserving our proprietary imaged capillary isoelectric focusing (icIEF) technology, which has been the go-to method for measuring charge heterogeneity. The whole-column detection eliminates the post-focusing mobilization step needed with traditional cIEF, and can resolve your most challenging molecules including fusion proteins and hydrophobic ADCs.
	My current method is not reproducible and error-prone Maurice employs a prequalified, ready-to-use cartridge design which fully automates column conditioning and clean up. No laborious capillary assembly or maintenance is required. The on-board sample mixing feature further enhances the ease-of-use, and reduces operator-dependent variability commonly encountered with other systems.
	I have many samples and my schedule is tight Maurice produces pI and charge heterogeneity data in less than 10 minutes, and size-based CE-SDS data in 35 minutes. The fast separation time, flexible workflow and high reproducibility makes Maurice a true lab workhorse. In one day you can complete your method development, or analyze 48 to 100 samples in one batch. The icing? You can develop platform methods and use them for multiple molecules too.
	I am concerned about cross-contamination between applications Maurice employs completely separate fluid paths for cIEF and CE-SDS applications. Waste is collected inside the cartridge which removes the concern about cross-contamination between experiments. In addition, when dealing with molecules such as ADCs, no more hassle about handling the toxic waste.
	My sample is limited and they tend to aggregate at high concentration Maurice's native fluorescence detection for cIEF provides 3-5X higher sensitivity than UV absorption, which means you can now measure sample at concentration as low as 0.7 µg/ml. And because proteins tend to aggregate less at lower concentrations you can reduce or even eliminate urea completely in some of your methods. Baselines are also significantly cleaner and less sensitive to ampholyte interference, giving you more options when optimizing your pH gradient.
	I work in a GMP lab and data integrity is key to my compliance requirement Compass for iCE, the software package Maurice uses to acquire, manage and analyze data, has all the tools required for 21 CFR compliance so you'll have no issue analyzing biotherapeutics on Maurice in a regulated environment.

Citations for Maurice

View all citations for the Imaged Capillary Electrophoresis (iCE) platform.
Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.

Testimonials from your Peers for Imaged Capillary Electrophoresis (iCE)

Showing 1 - 5 of 6 testimonials Showing All

"For charge variant analysis, we have largely replaced ion exchange chromatography with the icIEF on the Maurice system….. Once we brought it in-house, it was the ideal platform for us - the icIEF fractionation capability enabled us to get further insights into the charge variants."

Quality Assistance: Utilizing Maurice Platforms to Help Customers Bring New Biotherapeutics to Patients in Need

Arnaud Delobel, PhD, Director, R&D and Innovation Quality Assistance

"Imaged cIEF, also known as icIEF, is a platform analytical technology and offers not only high throughput with a quick turn-around of ~10-min per sample, but also quantitation capability for charge variants, while maintaining the highest resolution of IEF technology."

The Advantages of Implementing icIEF in the Lab

Xiaoping He, Sr. Principal Scientist, Pfizer (retired)

"Adding fractionation capabilities can really help in simplifying the workflow to assess peak identity, especially if paired with state-of-the-art mass spectrometry techniques. On top of this, the experience of working with the Bio-Techne family has been a pleasure so far and they helped us throughout our first work, beyond the training aspect of the installation."

Streamlining Charge Variant Analysis with MauriceFlex

Dr. Sara Carillo, Bioanalytical Research Lead, NIBRT

"Replacing preparative chromatography with MauriceFlex has made the process of fraction collection more efficient."

The MauriceFlex™ System in Action: Accelerating Protein Charge Variant Characterization

Amreen Jonas, Principal Associate Scientist, Mersana Therapeutics

"I think that the data we produced [on Maurice] shows excellent quality, due to the precise and reliable Maurice instrument."

Automated Capillary Electrophoresis: A Technological Renaissance at the Heart of Biopharmaceuticals

Professor Hermann Wätzig, Technical University of Braunschweig in Germany

Showing 1 - 5 of 6 testimonials Showing All

More Information About Maurice

How Does Maurice Work?

Applications

Products Compatible with Maurice

Specifications

Feature	cIEF Specification	CE-SDS Specificiation
Minimum Sample Volume	50 µL	50 µL
Sample Delivery	Vacuum	Electrokinetic
Typical Separation Time	6–10 min (molecule-dependent)	Reduced IgG: 25 min, Non-reduced IgG: 35 min
Detection Capability	UV Absorbance at 280 nm Fluorescence: Ex 280 nm, Em 320– 450 nm	UV Absorbance at 220 nm
Typical Voltage	Pre-focusing: 1500 V, focusing: 3000 V	Separation: 5750 V
Sample Injections per Cartridge	100 guaranteed, 200 maximum	100 guaranteed, 200 maximum for CE-SDS, 500 maximum for CE-SDS PLUS
Maximum Sample Injections per Batch	100	48
pI/Size Range	2.85–10.45	10–270 kDa
pI/Sizing CV	0.01	≤2%
CV for Peaks >10% Composition	≤5% (Intra-batch), ≤6% (Inter-batch)	N/A
Relative Migration Time CV	N/A	<1% for reduced IgG
pI/Sizing Resolution	0.05 pI units (for wide range 3–10 ampholytes)	≥1.5 for NGHC/HC IgG Standard
Dynamic Range	2 logs	2 logs
Linearity	>0.995	>0.995
Sensitivity (LOD)	0.7 µg/mL (Native fluorescence) 3.0 µg / mL(Absorbance) (Values based on a monoclonal antibody)	0.3 µg/mL (Value based on Internal Standard)
Sample Tray Options	96-well plates or 48 vials
Dimensions	44cm H x 42cm W x 61cm D
Weight	46 kg (100 lb)

Product Documents for Maurice

Datasheet

Download 95-5004-00 Maurice datasheet revF DIGITAL

Protocols & Manuals

Download 046-295 revE Maurice User Guide

Download 046-296 RevD Maurice cIEF Method Development Guide web

Download 046-297 Maurice CE-SDS Application Guide RevH DIGITAL

Download PL2-0022 RevB Maurice Chromeleon User Guide

Maurice CE-SDS and icIEF Instrument

ProteinSimple, part of Bio-Techne | Catalog # 090-000

Your workhorse station for purity, identity and heterogeneity analysis

Purity, identity and heterogeneity

Available Services

How Can Maurice Help You?

My molecule has complicated charge profiles that are difficult to resolve

My current method is not reproducible and error-prone

I have many samples and my schedule is tight

I am concerned about cross-contamination between applications

My sample is limited and they tend to aggregate at high concentration

I work in a GMP lab and data integrity is key to my compliance requirement