Omeprazole

Name: Omeprazole
Brand: Tocris Bioscience
SKU: 2583
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2583

(1)

COA / SDS

H+,K+-ATPase inhibitor

Discontinued Product

2583 has been discontinued. View all H+/K+ ATPase Inhibitors products.

Key Product Details

Description:	H⁺,K⁺-ATPase inhibitor
Chemical Name:	5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
Purity:	≥99% (HPLC)
Molecular Weight:	345.42

View Full Technical Details for Omeprazole

Technical Data
Citations / Reviews (1)

Biological Activity for Omeprazole

Omeprazole is a H⁺,K⁺-ATPase inhibitor (IC₅₀ = 5.8 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC₅₀ = 0.16 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro. Also inhibits CYP2C19, CYP2C9 and CYP3A (K_i values are 3.1, 40.1 and 84.4 μM respectively) and blocks swelling-dependent chloride channels (ICIswell). Enhances anti-SARS-CoV-2 acitvity of Remdesivir and Aprotinin (Cat. No. 4139).

Technical Data for Omeprazole

M. Wt	345.42
Formula	C₁₇H₁₉N₃O₃S
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	73590-58-6
PubChem ID	4594
InChi Key	SUBDBMMJDZJVOS-UHFFFAOYSA-N
Smiles	COC1=CC=C2N=C(NC2=C1)S(=O)CC1=C(C)C(OC)=C(C)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Omeprazole

References are publications that support the biological activity of the product.

Bojkova SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles. BioRxiv - Paper not yet peer reviewed.
Richardson Proton pump inhibitors. Drugs 1998 PMID: 9777309
Schmarda The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. Br.J.Pharmacol. 2000 PMID: 10711360
Satoh Antisecretory and anitulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J.Pharmacol.Exp.Ther. 1989 PMID: 2537418

Omeprazole

Tocris Bioscience, part of Bio-Techne | Catalog # 2583

Key Product Details

Biological Activity for Omeprazole

Technical Data for Omeprazole

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Omeprazole

Product Documents for Omeprazole

COA

Certificate of Analysis

SDS

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