trans-4-Hydroxycrotonic acid
Tocris Bioscience, part of Bio-Techne | Catalog # 0538
GHB receptor ligand
Discontinued Product
0538 has been discontinued.
View all Additional GABA Compounds products.
Product Description
Binds to the γ-hydroxybutyric acid (GHB) receptor with higher affinity than GHB itself. May be an endogenous ligand.Product Specifications
Molecular Weight
102.09
Formula
C4H6O3
Storage
Desiccate at +4°C
Purity
≥99% (HPLC)
Chemical Name
trans-4-Hydroxy-2-butenoic acid
CAS Number
24587-49-3
PubChem ID
6155526
InChI Key
RMQJECWPWQIIPW-OWOJBTEDSA-N
SMILES
OC\C=C\C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.21 | 100 |
Preparing Stock Solutions
for trans-4-Hydroxycrotonic acid
The following data is based on the product molecular weight 102.09
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 9.80 mL | 48.98 mL | 97.95 mL |
| 5 mM | 1.96 mL | 9.80 mL | 19.59 mL |
| 10 mM | 0.98 mL | 4.90 mL | 9.80 mL |
| 50 mM | 0.20 mL | 0.98 mL | 1.96 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hechler Gamma hydroxybutyrate ligands posses antiDArgic and neuroleptic-like activities. J.Pharmacol.Exp.Ther. 1993 PMID: 8095552
- Vayer Natural occurrence of trans-gamma hydroxycrotonic acid in rat brain. Biochem.Pharmacol. 1985 PMID: 4015683
- Bourguignon Analogues of γ-hydroxybutyric acid. Synthesis and binding studies. J.Med.Chem. 1988 PMID: 3361576
Product Specific Notices for trans-4-Hydroxycrotonic acid
For research use only
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