Rose Bengal

Name: Rose Bengal
Brand: Tocris Bioscience
SKU: 5168
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5168

(1)

Citations (3)

COA / SDS

Stains exposed epithelium in eye. Also VGlut and VMAT inhibitor

Discontinued Product

5168 has been discontinued. View all Glutamate (EAAT) Transporter Inhibitors products.

Key Product Details

Description:	Stains exposed epithelium in eye. Also VGlut and VMAT inhibitor
Chemical Name:	4,5,6,7-Tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one disodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	1017.64

View Full Technical Details for Rose Bengal

Technical Data
Citations / Reviews (1)

Biological Activity for Rose Bengal

Rose Bengal is a potent VGlut and vesicular monoamine transporter (VMAT) inhibitor (K_i values are 19 and 64 nM, respectively). Inhibits ATP dependent vesicular glutamate uptake (IC₅₀ = 37 nM) and diminishes the amount of exocytotically released glutamate in synaptosomes. Decreases synaptic transmission in the dentate gyrus. Also stains exposed epithelium in the eye. Cell permeable.

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Technical Data for Rose Bengal

M. Wt	1017.64
Formula	C₂₀H₂Cl₄I₄Na₂O₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	632-69-9
PubChem ID	32343
InChi Key	UWBXIFCTIZXXLS-UHFFFAOYSA-L
Smiles	O=C2C(I)=CC(C(OC3=C(I)C(O[Na])=C(I)C=C34)=C2I)=C4C1=C(C(O[Na])=O)C(Cl)=C(Cl)C(Cl)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Rose Bengal

References are publications that support the biological activity of the product.

Feenstra What is actually stained by rose bengal? Arch.Ophthalmol. 1992 PMID: 1637285
Ogita Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal. J Neurochem. 2001 PMID: 11279259
Neale Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology. Neuropsychopharmacology 2013 PMID: 23303071
Pietrancosta Rose Bengal analogs and vesicular glutamate transporters (VGLUTs). Bioorg.Med.Chem. 2010 PMID: 20708942