ING-2 AM
Tocris Bioscience, part of Bio-Techne | Catalog # 7870
Fluorescent sodium ion (Na+) indicator, membrane permeable
Discontinued Product
7870 has been discontinued.
View all Ion Indicators products.
Key Product Details
Description
Fluorescent sodium ion (Na+) indicator, membrane permeable
Product Description
ING-2 AM is a membrane-permeable fluorescent sodium ion (Na+) indicator. It binds to sodium (Kd = 20 mM). Excitation and emission maxima (λ) are 525 and 545 nm, respectively. It displays 20-fold selectivity over K+ ions. It is used in in vitro and in situ to detect real-time sodium influx.It is recommended to prepare stock solutions in DMSO.
Optical Data
| λabs | 525 nm |
| λem | 545 nm |
| Cell Permeable | Yes |
| Application | Confocal microscopy, Flow cytometry, Two-photon microscopy |
Spectra Viewer
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Spectra ViewerProduct Specifications
Molecular Weight
1083.96
Formula
C53H60Cl2N2O18
Storage
Store at -20°C
Purity
≥90% (HPLC)
Chemical Name
Bis(acetoxymethyl) 3,3'-(6-(acetoxymethoxy)-4,5-dichloro-9-(3-methoxy-4-(13-(2-methoxy-4-methylphenyl)-1,4,10-trioxa-7,13-diazacyclopentadecan-7-yl)phenyl)-3-oxo-3H-xanthene-2,7-diyl)dipropionate
CAS Number
1642554-49-1
PubChem ID
163341954
InChI Key
OTIAVQNFWAJQKZ-UHFFFAOYSA-N
SMILES
O=C(C)OCOC(CCC1=CC2=C(C3=CC(OC)=C(N4CCOCCOCCN(CCOCC4)C5=CC=C(C)C=C5OC)C=C3)C6=C(C(Cl)=C(C(CCC(OCOC(C)=O)=O)=C6)OCOC(C)=O)OC2=C(C1=O)Cl)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Background References
References are publications that support the biological activity of the product.
- Roder ANG-2 for quantitative Na(+) determination in living cells by time-resolved fluorescence microscopy. Photochem.Photobiol.Sci. 2014 PMID: 25311309
- Blömer Ultrafast sodium imaging of the axon initial segment of neurons in mouse brain slices. Curr.Protoc. 2021 PMID: 33657273
- Naumann Photophysical properties of Na+ -indicator dyes suitable for quantitative two-photon fluorescence-lifetime measurements. J.Microsc. 2018 PMID: 30191999
- Gregoriades Genetic and pharmacological inactivation of apical Na+-K+-2Cl- cotransporter 1 in choroid plexus epithelial cells reveals the physiological function of the cotransporter. Am.J.Physiol.Cell Physiol. 2019 PMID: 30576237
Product Specific Notices for ING-2 AM
For research use only
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