Pelitinib

Tocris Bioscience, part of Bio-Techne | Catalog # 6349

Potent and irreversible EGFR inhibitor; orally bioavailable
Discontinued Product
6349 has been discontinued. View all EGF Receptor Inhibitors products.

Key Product Details

Description

Potent and irreversible EGFR inhibitor; orally bioavailable

Alternative Names

EKB-569

View all EGF Receptor Inhibitors »

Product Description

Pelitinib is a potent irreversible EGFR inhibitor (IC50 = 20-80 nM). Selective for EGFR over Src, MEK/ERK, erbB2, Raf, c-Met and Cdk4 (IC50 values are 282, 800, 1255, 3353, 4100 and >20,000). Inhibits the growth of tumors overexpressing EGFR in vivo. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Product Specifications

Molecular Weight

467.92

Formula

C24H23ClFN5O2

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide

CAS Number

257933-82-7

PubChem ID

6445562

InChI Key

WVUNYSQLFKLYNI-AATRIKPKSA-N

SMILES

O=C(/C=C/CN(C)C)NC1=C(OCC)C=C(N=CC(C#N)=C2NC3=CC=C(F)C(Cl)=C3)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.4 50

Preparing Stock Solutions for Pelitinib

The following data is based on the product molecular weight 467.92

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.27 mL 21.37 mL 42.74 mL
2.5 mM 0.85 mL 4.27 mL 8.55 mL
5 mM 0.43 mL 2.14 mL 4.27 mL
25 mM 0.09 mL 0.43 mL 0.85 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Product Documents for Pelitinib

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pelitinib

For research use only

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