Tipifarnib
Tocris Bioscience, part of Bio-Techne | Catalog # 6410
Potent farnesyltransferase inhibitor; orally bioavailable
Discontinued Product
6410 has been discontinued.
View all Protein Prenyltransferase Inhibitors products.
Key Product Details
Description
Potent farnesyltransferase inhibitor; orally bioavailable
Product Description
Tipifarnib is a potent farnesyltransferase inhibitor. Inhibits farnesylation of lamin B and K-RasB peptide substrates (IC50 values are 0.86 and 7.9 nM, respectively). Inhibits tumor growth in vitro and in vivo. Cell penetrant and orally bioavailable.Product Specifications
Molecular Weight
489.40
Formula
C27H22Cl2N4O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl}-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
CAS Number
192185-72-1
PubChem ID
159324
InChI Key
PLHJCIYEEKOWNM-HHHXNRCGSA-N
SMILES
CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC=C4N(C(C=C(C4=C3)C5=CC(Cl)=CC=C5)=O)C)N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.94 | 100 | |
| Ethanol | 9.79 | 20 |
Preparing Stock Solutions
for Tipifarnib
The following data is based on the product molecular weight 489.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.04 mL | 10.22 mL | 20.43 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.09 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.04 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- End Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 2001 PMID: 11196150
Product Specific Notices for Tipifarnib
For research use only
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