L002
Tocris Bioscience, part of Bio-Techne | Catalog # 5045
p300 inhibitor
Discontinued Product
5045 has been discontinued.
View all Histone Acetyltransferase Inhibitors products.
Product Description
L002 is a p300 inhibitor (IC50 = 1.98 μM). Inhibits histone and p53 acetylation, and suppresses STAT3 activation in cell-based assays. Also suppresses tumor growth in a mouse MDA-MB-468 xenograft model.Product Specifications
Molecular Weight
321.35
Formula
C15H15NO5S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione
CAS Number
321695-57-2
PubChem ID
2221149
InChI Key
VEWFTYOFWIXCIO-UHFFFAOYSA-N
SMILES
O=C(C(C)=C2)C(C)=C\C2=N/OS(C1=CC=C(OC)C=C1)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.13 | 100 | |
| Ethanol | 3.21 | 10 with gentle warming |
Preparing Stock Solutions
for L002
The following data is based on the product molecular weight 321.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.11 mL | 15.56 mL | 31.12 mL |
| 5 mM | 0.62 mL | 3.11 mL | 6.22 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.11 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yang Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Mol.Cancer Ther. 2013 PMID: 23625935
Product Specific Notices for L002
For research use only
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