TrkA Antibody (RM423)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-09176

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-09176-100ul
NBP3-09176-25ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM423 expressed in HEK293

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TrkA Antibodies »

Product Specifications

Immunogen

A peptide corresponding to the C-terminus of human TrkA

Reactivity Notes

This antibody may also react to mouse or rat TrkA, as predicted by immunogen homology

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

Novus Biologicals Rabbit TrkA Antibody (RM423) (NBP3-09176) is a recombinant monoclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for TrkA Antibody (RM423)

Western Blot: TrkA Antibody (RM423) [NBP3-09176]

Western Blot: TrkA Antibody (RM423) [NBP3-09176]

Western Blot: TrkA Antibody (RM423) [NBP3-09176] - Western Blot of mouse brain tissue lysate using NBP3-09176 at a 1:2000 dilution.
Immunohistochemistry-Paraffin: TrkA Antibody (RM423) [NBP3-09176]

Immunohistochemistry-Paraffin: TrkA Antibody (RM423) [NBP3-09176]

Immunohistochemistry-Paraffin: TrkA Antibody (RM423) [NBP3-09176] - Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using NBP3-09176 at a 1:100 dilution.

Applications for TrkA Antibody (RM423)

Application
Recommended Usage

Immunohistochemistry

1:100 - 1:200

Western Blot

1:1000 - 1:2000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C.

Background: TrkA

The Trk proto-oncogene encodes a 140 kDa, membrane-spanning protein tyrosine kinase that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that Trk A binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of Trk A as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF (1). Trk A was found to be expressed in the nervous system and phosphorylated in response to NGF (Nerve Growth Factor). Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes (2). Trk A is expressed in neural and nonneuronal tissues. Like RET, Trk A is often activated by rearrangements that involve one of at least five other genes in papillary thyroid carcinoma (PTC) (3).

Long Name

Neurotrophic Tyrosine Kinase Receptor A

Alternate Names

NTRK-1, NTRK1

Gene Symbol

NTRK1

Additional TrkA Products

Product Documents for TrkA Antibody (RM423)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TrkA Antibody (RM423)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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