Rotavirus Antibody (0581)

Novus Biologicals, part of Bio-Techne | Catalog # NB100-63041

Novus Biologicals, part of Bio-Techne
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NB100-63041
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Key Product Details

Species Reactivity

Virus

Applications

ELISA

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 0581

Concentration

0.1 mg/ml

View all Rotavirus Antibodies »

Product Specifications

Immunogen

Made to Viral ROTAVIRUS

Specificity

NB100-63041 detects intact Rotavirus strains RRV, Wa and Bovine. Rotavirus is a member of the Reoviridae family, and is the leading cause of diarrhoea hospitalisation among children worldwide. Seven major groups have been identified, of which three (groups A, B, and C) infect humans. Group A is the most common and widespread.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Rotavirus Antibody (0581)

Application
Recommended Usage

ELISA

1:20-1:200

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Rotavirus

Rotaviruses, members of the family Reoviridae, are a major cause of diarrhoea in young mammals. Rotavirus infections also result in economic losses in agriculture due to diarrhoea in calf, pig, sheep, and poultry rearing. Diarrhoea (or scours) due to the rotavirus Nebraska Calf Diarrhea Virus can affect calves up to 30 days of age or older. Diarrhoea begins 2 to 3 days after exposure. Diagnosis is by history, lesions (ulcers on the tongue, lips, and mouth) and diagnostic laboratory tests. Mortality rates may be as high as 50 percent, depending on the secondary bacteria present. Human rotaviruses, the major aetiological agents of severe infantile diarrhoea worldwide, display surprisingly diverse and complex serotypic specificities. Rotaviruses are 70 nm, non enveloped viruses comprised of a triple layered protein capsid; Outer capsid proteins are VP4 and VP7, Inner capsid -VP6 and Core -VP2. The immunity acquired from exposure to rotavirus appears to be type specific following initial infection; therefore, multiple serotypes of rotavirus mean multiple opportunities for infection. The combination of animal reservoirs for the virus and rotavirus gene reassortment provides the potential for dramatic genetic shifts (similar to influenza virus) which could give rise to altered host ranges and viral virulence.

Alternate Names

Major inner capsid protein VP6, VP6

Additional Rotavirus Products

Product Documents for Rotavirus Antibody (0581)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Rotavirus Antibody (0581)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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