Rab7a Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-05048

Discontinued Product
NBP1-05048 has been discontinued. View all Rab7a products.

Key Product Details

Species Reactivity

Human, Mouse, Rat, Bovine, Canine, Sheep

Applications

Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all Rab7a Antibodies »

Product Specifications

Immunogen

Recombinant full length human RAB7A protein

Localization

Late endosome, lysosome, cytoplasmic vesicle, phagosome, melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Marker

Late Endosome Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

23 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Applications for Rab7a Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100

Western Blot

1:1000
Application Notes
In Western blot, a band is seen ~23 kDa.

Reviewed Applications

Read 2 reviews rated 4 using NBP1-05048 in the following applications:

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Whole antisera

Preservative

0.1% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Rab7a

RAB7A (Ras-related protein Rab-7a), a member of small GTPase superfamily/Rab family, is widely expressed with highest expression levels in skeletal muscles and localize to late endosome, lysosome, phagosome, melanosome etc. It colocalizes with OSBPL1A at the late endosome and interacts with RAC1, NTRK1/TRKA, RILP, PSMA7, RNF115, FYCO1, OSBPL1A, CLN3, and PIK3C3/VPS34-PIK3R4 complex. RAB7A is a major player in endo-lysosomal trafficking and it directs the early-to-late endosomal maturation, microtubule minus/plus-end directed endosomal migration as well as positioning, and endosome-lysosome transport through different protein-protein interaction cascades. RAB7A regulates growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in neuronal axons, lipid metabolism, pathogen infections including viral life cycle and regulation of certain specialized endosomal membrane trafficking such as melanosomes maturation, pathogen-induced phagosomes, autophagosomes etc. With RAC1, RAB7A controls the ruffled borders formation in osteoclasts. It also regulate endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA, and endocytic trafficking of EGF-EGFR complex. Defects in RAB7A have been linked to Charcot-Marie-Tooth disease type 2B (CMT2B).

Long Name

RAs Genes from Brain Protein 7a

Alternate Names

PRO2706, RAB7

Entrez Gene IDs

7879 (Human); 19349 (Mouse); 29448 (Rat)

Gene Symbol

RAB7A

UniProt

P51149 (Human)

Additional Rab7a Products

Product Documents for Rab7a Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Rab7a Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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