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p21/CIP1/CDKN1A Antibody (A8C11-R)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-32692

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-32692

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Mouse IgG1 Clone # A8C11-R

Concentration

1 mg/ml

Product Specifications

Immunogen

Recombinant protein within full length of human p21/CIP1/CDKN1A. (Uniprot: P38936)

Localization

Nucleus, Cytoplasm.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

18 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for p21/CIP1/CDKN1A Antibody (A8C11-R)

p21/CIP1/CDKN1A Antibody (A8C11-R)

Immunohistochemistry: p21/CIP1/CDKN1A Antibody (A8C11-R) [NBP3-32692]

Immunohistochemistry: p21/CIP1/CDKN1A Antibody (A8C11-R) [NBP3-32692] - Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue with Mouse anti-p21/CIP1/CDKN1A antibody (NBP3-32692) at 1/200 dilution.

The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 2 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (NBP3-32692) at 1/200 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

Applications for p21/CIP1/CDKN1A Antibody (A8C11-R)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:200-1:400

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH7.4), 0.1% BSA and 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: p21/CIP1/CDKN1A

Cell cycle progression is regulated by cyclins and their cognate Cdks. p21 (WAF1/CIP1) inhibits the activity of each member of the cyclin/Cdk family, and over expression of this protein inhibits the proliferation of mammalian cells. The expression of p21 is inducible by a wide range of stress stimuli. p21 is tightly regulated at the transcriptional level by p53, and probably serves as the effector of p53 cell cycle control.

Long Name

p21 Cyclin Dependent Kinase 4 Inhibitor 1A

Alternate Names

CDKN1A, CIP1

Gene Symbol

CDKN1A

Additional p21/CIP1/CDKN1A Products

Product Documents for p21/CIP1/CDKN1A Antibody (A8C11-R)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for p21/CIP1/CDKN1A Antibody (A8C11-R)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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