MRCL3 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-46979

Novus Biologicals, part of Bio-Techne
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NBP3-46979
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Western Blot, ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MRCL3 Antibodies »

Product Specifications

Immunogen

myosin, light chain 12A, regulatory, non-sarcomeric. (Uniprot# P19105)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Novus Biologicals Rabbit MRCL3 Antibody - BSA Free (NBP3-46979) is a polyclonal antibody validated for use in IHC, WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for MRCL3 Antibody - BSA Free

MRCL3 Antibody - BSA Free

Western Blot: MRCL3 Antibody - BSA Free [NBP3-46979] -

Western Blot: MRCL3 Antibody - BSA Free [NBP3-46979] - NIH/3T3 cells were subjected to SDS PAGE followed by western blot with (MRCL3 Antibody) at dilution of 1:600
MRCL3 Antibody - BSA Free

Immunohistochemistry: MRCL3 Antibody - BSA Free [NBP3-46979] -

Immunohistochemistry: MRCL3 Antibody - BSA Free [NBP3-46979] - Immunohistochemistry of paraffin-embedded human heart tissue slide using (MRCL3 Antibody) at dilution of 1:50

Applications for MRCL3 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:20-1:200

Western Blot

1:500-1:2000
Application Notes
Theoretical Molecular Weight is 19-20 kDa

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 50% Glycerol, pH (7.3)

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: MRCL3

The muscle myosins and hexomeric proteins consisting of two heavy chains and two pairs of light chains, the latter called essential (ELC) and regulatory (RLC). The light chains stabilize the long alpha helical neck of the myosin head (1). Human myosin light chain-2 (MYL2) is an important protein involved in the regulation of myosin ATPase activity in smooth muscle. In cardiac muscle, the precise role of MYL2 is not well understood; however, an increase in ventricular MYL2 is observed during myocardial hypertrophy in cardiac patients with valve stenosis (2). Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant disease caused by mutations in all of the major sarcomeric proteins, including the ventricular myosin regulatory light-chain (RLC). The Myosin RLC mutation has been associated with a rare variant of cardiac hypertrophy defined by mid-left ventricular obstruction due to papillary muscle hypertrophy. This mutation was later found to cause ventricular and septal hypertrophy (3).

Alternate Names

MLCBMyosin RLC, MRCL3, MRLC3MLC-2B, MYL2B, myosin regulatory light chain 12A, Myosin regulatory light chain 2, nonsarcomeric, myosin regulatory light chain 3, myosin regulatory light chain MRCL3, Myosin regulatory light chain MRLC3, myosin, light chain 12A, regulatory, non-sarcomeric, myosin, light polypeptide, regulatory, non-sarcomeric (20kD), RLC

Gene Symbol

MYL12A

Additional MRCL3 Products

Product Documents for MRCL3 Antibody - BSA Free

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Product Specific Notices for MRCL3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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