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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot, Immunocytochemistry

Label

Alexa Fluor 532 (Excitation = 534 nm, Emission = 553 nm)

Antibody Source

Polyclonal Goat IgG

Product Specifications

Immunogen

E. coli-derived recombinant human LITAF
Met1-Ala111
Accession # Q99732

Specificity

Detects human LITAF in Western blots.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human LITAF Alexa Fluor® 532-conjugated Antibody

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: LITAF

LITAF (LPS-induced TNF- alpha factor), initially identified through its interaction with the TNF-alpha promoter, is a transcription factor that contributes to the regulation of several inflammatory cytokines in response to LPS or p53 stimulation. LITAF interacts directly with LPS-induced STAT6(B) in the cytoplasm, this complex then translocates into the nucleus, where it significantly up-regulates the transcription of other inflammatory mediators such as, GRO, IL-1 alpha, TNF-alpha, MCP-2 and IFN-gamma. Phosphorylation of LITAF by p38 alpha via the TLR pathway is also required for nuclear translocation. Mutations in LITAF have been associated with CMT1C
(Charcot‑Marie-Tooth neuropathy type 1C) an autosomal dominant demyelinating form of peripheral neuropathy.

Long Name

Lipopolysaccharide-induced TNF Factor

Alternate Names

PIG7, SIMPLE, TP53I7

Entrez Gene IDs

9516 (Human); 56722 (Mouse); 65161 (Rat)

Gene Symbol

LITAF

UniProt

Additional LITAF Products

Product Documents

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human LITAF Alexa Fluor® 532-conjugated Antibody


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

For research use only

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