Human CD11b/Integrin alpha M APC-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB1699A

Discontinued Product
FAB1699A has been discontinued. An alternative/replacement product is available: FAB1699R. View all CD11b/Integrin alpha M products.

Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # ICRF44

View all CD11b/Integrin alpha M Antibodies »

Product Specifications

Immunogen

Human rheumatoid synovial cells and monocytes

Specificity

Detects human Integrin alphaM/CD11b.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Human CD11b/Integrin alpha M APC-conjugated Antibody

Detection of Integrin aM/CD11b antibody in Human Blood Monocytes antibody by Flow Cytometry.

Detection of Integrin alphaM/CD11b in Human Blood Monocytes by Flow Cytometry.

Human peripheral blood monocytes were stained with Mouse Anti-Human Integrin aM/CD11b APC-conjugated Monoclonal Antibody (Catalog # FAB1699A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Human CD11b/Integrin alpha M APC-conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: Human peripheral blood monocytes

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Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CD11b/Integrin alpha M

The Integrin family proteins are heterodimeric transmembrane receptors composed of an alpha and a beta subunit. The Integrin alphaM subunit, also known as MAC-1 alpha subunit or CD11b, combines with the Integrin beta2 subunit (CD18) to form the non-covalent heterodimer Integrin alphaM/ beta2, also known as MAC-1 and complement receptor type 3 (CR3). Integrin alphaM/ beta2 is expressed on granulocytes, macrophages, dendritic cells and natural killer cells. Upon activation, alphaM/ beta2 can bind several ligands (including ICAM-1, fibrinogen and the C3 complement fragment C3bi) to mediate phagocyte adhesion, migration and ingestion of complement-opsonized particles.

Alternate Names

CD11b, Integrin alpha M, ITGAM

Entrez Gene IDs

3684 (Human); 16409 (Mouse)

Gene Symbol

ITGAM

Additional CD11b/Integrin alpha M Products

Product Documents for Human CD11b/Integrin alpha M APC-conjugated Antibody

Product Datasheets

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Product Specific Notices for Human CD11b/Integrin alpha M APC-conjugated Antibody

For research use only

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