DOK6 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-32609

Novus Biologicals, part of Bio-Techne
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NBP2-32609
NBP2-32609-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (98%), Rat (98%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all DOK6 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: WHHITRQNSVGEIYSLQGHGFGSSKMSRAQTFPSYAPEQSEEAQQPLSRSSSYGFSYSSSLIQ

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DOK6 Antibody - BSA Free

Immunohistochemistry: DOK6 Antibody [NBP2-32609]

Immunohistochemistry: DOK6 Antibody [NBP2-32609]

Immunohistochemistry: DOK6 Antibody [NBP2-32609] - Staining of lymphoma.
Immunohistochemistry: DOK6 Antibody [NBP2-32609]

Immunohistochemistry: DOK6 Antibody [NBP2-32609]

Immunohistochemistry: DOK6 Antibody [NBP2-32609] - Staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells.
Immunohistochemistry: DOK6 Antibody [NBP2-32609]

Immunohistochemistry: DOK6 Antibody [NBP2-32609]

Immunohistochemistry: DOK6 Antibody [NBP2-32609] - Staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells.
View 1 more images

Applications for DOK6 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DOK6

The downstream of kinase family (Dok1-6) are members of a class of "docking" proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. The gene encoding human Dok-5 maps to chromosomal location 20q13.2. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.

Long Name

Downstream of Tyrosine Kinase 6

Alternate Names

DOK5L

Gene Symbol

DOK6

Additional DOK6 Products

Product Documents for DOK6 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DOK6 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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