Abacavir hemisulfate
Tocris Bioscience, part of Bio-Techne | Catalog # 4148
Reverse transcriptase inhibitor; antiretroviral
Discontinued Product
4148 has been discontinued.
View all RNA/DNA Polymerase Inhibitors products.
Key Product Details
Description
Reverse transcriptase inhibitor; antiretroviral
Product Description
Abacavir hemisulfate is a competitive reverse transcriptase inhibitor; inhibits HIV replication. Orally active and brain penetrant. Antiretroviral agent.Licensing Information
Sold for research purposes under agreement from Viiv.Product Specifications
Molecular Weight
335.37
Formula
C14H18N6O.½H2SO4
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol hemisulfate
CAS Number
188062-50-2
PubChem ID
75539558
InChI Key
WMHSRBZIJNQHKT-NHMRBCHTSA-N
SMILES
OS(O)(=O)=O.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.54 | 100 | |
| DMSO | 16.77 | 50 |
Preparing Stock Solutions
for Abacavir hemisulfate
The following data is based on the product molecular weight 335.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.98 mL | 14.91 mL | 29.82 mL |
| 5 mM | 0.60 mL | 2.98 mL | 5.96 mL |
| 10 mM | 0.30 mL | 1.49 mL | 2.98 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Harrigan Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor aba. (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group. J.Infect.Dis. 2000 PMID: 10720512
- Daluge 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. Antimicrob Agents Chemother. 1997 PMID: 9145874
- Charneira N-terminal valine adduct from the anti-HIV drug aba. in rat haemoglobin as evidence for aba. metabolism to a reactive aldehyde in vivo. Br.J.Pharmacol. 2012 PMID: 22725138
Product Specific Notices for Abacavir hemisulfate
For research use only
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