Lys-[Des-Arg9]Bradykinin
Tocris Bioscience, part of Bio-Techne | Catalog # 3225
Selective B1 agonist
Discontinued Product
3225 has been discontinued.
View all Bradykinin Receptor Agonists products.
Key Product Details
Description
Selective B1 agonist
Alternative Names
Des-Arg10-Kallidin
Product Description
Lys-[Des-Arg9]Bradykinin is an endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripheral vascular resistance in vivo. 16-fold more potent than [Des-Arg9]-Bradykinin (Cat No. 3005).Product Specifications
Molecular Weight
1032.21
Formula
C50H73N13O11
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
71800-36-7
PubChem ID
122227
InChI Key
AILVBOHFGXNHCC-TZPCGENMSA-N
SMILES
[H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Regoli Classification of kinin receptors. Biol.Chem. 2001 PMID: 11258668
- Leeb-Lundberg International union of pharmacology. LV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 2005 PMID: 15734727
- Drapeau Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 1991 PMID: 1662280
Product Specific Notices for Lys-[Des-Arg9]Bradykinin
For research use only
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