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Optimize your formulation faster. Ensure that your product is stable in solution and sails through stability stress testing. Our high-throughput instruments will help you quickly identify the optimum salts, pH, and excipients for your formulations. High throughput analytical instrumentation efficiently compares the formulation effects of multiple buffer conditions on protein aggregation, degradation, and fragmentation. Each of these platforms operate in a bioprocessing environment with 21 CFR Part 11- compliant software, so you can be confident in the integrity of your results.

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Analytical Platforms

Simple Western Systems allow users to automate western blots for quick and accurate size and protein separation, while the charge immunoassay capabilities provide a way to assess post-translational modifications. Samples containing high salt, low concentrations of protein, or both typically require desalting and sample concentration procedures prior to analysis. This not only reduces throughput and increases time to results, but also can cause unwanted sample protein alterations. Chemiluminescent Simple Western assays are up to one thousand times more sensitive than absorbance-based methods and don’t need extra prep for high salt or low concentration samples. Simple Western Systems run up to 96 samples per run.

Jess Simple Western instrument by ProteinSimple, a Bio-Techne brand

Which buffer’s best? Finding the conditions that keep your protein stable isn’t exactly simple, but our instrument solutions help you narrow it all down faster. Maurice instruments perform automated cIEF and CE-SDS analyses. Maurice can run up to 100 samples/run at 6-10 minutes each for cIEF charge assay, and up to 48 samples/run at 25-35 minutes each for CE-SDS size assay.

Maurice: Automated cIEF and CE-SDS by ProteinSimple, a Bio-Techne brand

Micro-Flow Imaging analyzes protein aggregation for stability measurements following stress testing. With the MFI™ 5000 Series, you can detect those 1 μm to 100 μm aggregates that size- exclusion chromatography (SEC) has a hard time with. Detecting insoluble aggregates in the sub-visible range gives you early insight plus a better quantitative picture of your therapeutic’s stability. MFI can analyze up to 90 samples/run and up to 150 µL/minute at 900,000 particles/mL.

Micro-Flow Imaging MFI