Skip to main content

Express Discovery

Knowledge is power – obtaining as much high-quality information as possible early on in the protein bioprocessing workflow will be sure to set you up for success. When screening candidates and profiling immune responses can be done rapidly and effectively in the discovery stages, your downstream processes become quicker, cheaper and simpler.

Bio-techne can help you fast-track your discovery stages with automated and innovative solutions.
Luminex instruments and assays for use in protein bioprocessing workflows, immunology research and more

Multiplex with Luminex

Understanding how the immune system responds to your candidate therapeutic can make or break its success.

The earlier you have this data, the better - but running multiple assays for all your candidate therapeutics can take a lot of your sample, time and resources.

Discover a better way with ready-to-run and customizable Luminex cytokine panels. Save sample, time and money with quick, comprehensive immune profiling comparable to conventional assays – like ELISA and qPCR – with greater efficiency and throughput.

Simple Screening with Simple Western

Screening candidates is a key step in protein discovery – but the semi-quantitative, labor-intensive, and time-consuming nature of Western blotting can let you down.

Let our Simple Western™ platforms bring you back up! For super-fast, high-throughput antibody screening with quantitative results you can rely on, Simple Western technology is the simple choice.

The early bird catches the worm. Get ahead of your competition in the early stages of your workflow - rapidly perform charge distribution of mAbs, antibody screening, clone selection product titer, identity, and degradation analyses with Simple Western.

ProteinSimple Simple Western Instruments
ProteinSimple instrument Jess for chemiluminescence and fluorescence multiplexing.

Jess

Simple Western size assays using chemiluminescence or fluorescence

Multiplex protein quantification with best-in-class detection sensitivity.

  • Fully automated solution for up to 25 samples
  • Fully analyzed results in just 3 hours using just 3 µL of starting material
  • Multiplex using NIR/IR fluorescence and chemiluminescence 
  • Sequential immunoassays or total protein detection on the same sample with RePlex

 

ProteinSimple instrument Abby for chemiluminescence assays.

Abby

Simple Western size assays using chemiluminescence

Abby quickly gets you down to pg-level sensitivity with just 3 µL of starting material.

  • Fully automated solution
  • Process 25 samples in just 3 hours
  • Get up to 6 logs of dynamic range with HDR detection
  • RePlex lets you perform a second round of immunoassay or total protein detection in the same capillary

 

ProteinSimple instrument Milo for Single-Cell Westerns.

Milo

Single-Cell Westerns

Welcome to the world of Single-Cell Westerns!

  • Step away from population level resolution of Western blotting and off-target binding of flow cytometry, and embrace the Single-Cell Western revolution
  • Resolve single-cell heterogeneity in thousands of cells in just one run!

 

ProteinSimple instrument Sally Sue for high-throughput Simple Western size assays.

Sally Sue

High throughput Simple Western size assays using chemiluminescence

Sally Sue provides you with a fast and simple method to characterize proteins by size in up to 96 samples at a time.

  • Process 96 samples overnight
  • Separate and analyze proteins between 2 kDa and 440 kDa
  • Input as little as 0.2 µg/µL of protein in just 5 µL of sample
  • Immunoassay or total protein analysis

 

ProteinSimple instrument Peggy Sue for high-throughput charge assays.

Peggy Sue

High throughput Simple Western size and charge assays using chemiluminescence

Peggy Sue provides you with a fast and simple method to characterize proteins by size or charge in up to 96 samples at a time.

  • Separate and analyze proteins by size from 2-440 kDa or by charge from pI 3-10
  • Process 96 samples overnight
  • Input as little as 0.2 µg/µL of protein in just 5 µL of sample
  • Immunoassay or total protein analysis

 

Milo performs Western analysis on individual cells to provide insight into population heterogeneity

NanoPro 1000

Simple Western charge assays with chemiluminescence

NanoPro 1000 can give you all the charge heterogeneity details on your protein in as few as 25 cells and up to 96 samples at a time.

  • Process 96 samples overnight
  • Fully automated solution
  • Separate and analyze proteins between pI 3-10
  • Resolve protein isoforms like phosphorylated and glycosylated proteins in complex samples

 

 

Take Charge Of Discovery

Monitoring post-translational modifications through charge heterogeneity and IgG analysis of your protein therapeutic candidate is an important quality requirement for regulatory authorities. But, what if you could easily and quickly obtain this information during the discovery stages? You could make early, yet informed decisions on candidates – saving you precious time downstream.

Reproducible results in under 35 minutes!

Discover how to get quantitative analysis of identity, purity and heterogeneity profiles of biopharmaceuticals in a snap!

maurice c

Meet Maurice C

How about quantitative pl and charge heterogeneity analysis in less than 10 minutes?

maurice s

Meet Maurice S

Getting IgG purity analysis that meets regulatory requirements needn’t be laborious. With Maurice S’s ready-to-go CE-SDS or CE-SDS PLUS cartridges you get fast and robust IgG purity data in just 35 minutes.

ice3

iCE3

With iCE3 you can get high-resolution, quantitative charge heterogeneity data in less time than it takes to have a cup of coffee. It'll analyze your toughest samples and most challenging proteins with ease.

Detect, Visualize, and Validate Early With RNAScope™

Be confident in your therapeutic and validate specificity, safety, and efficacy early on by seeing it with your own eyes. With RNAscope you can visualize the spatial expression and biodistribution of target(s) across multiple tissues.

What’s more?

Get orthogonal validation with lower background noise compared to traditional RNA detection techniques and super sensitivity - only 6 Z pairs are required to obtain a signal. Or check out BaseScope™ Assays that are even further refined to detect as few as 1-3 Z pairs!

Take things one step further with RNA-Protein Co-Detection Assays

If you need to simultaneously examine cell-type specific gene expression and identify cellular sources of secreted proteins, RNA-Protein Co-Detection assays have got you covered.

protein bioprocessing
Exosomes

Extend Your Capabilities with Exosome Diagnostics

RNA, DNA and protein profiling can accelerate your discovery process – but conventional cell lysis techniques can destroy important material and disturb cell conditions.

Exosome isolation with Exolution Plus will keep your RNA, DNA and proteins safe and intact – allowing you to perform longitudinal and dynamic analysis with confidence.

Discover a better way to profile your analytes with Exolution Plus.