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Siglec-1/CD169 Products

Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: Siglecs-1, -2, and -4, and a Siglec-3/CD33-related subgroup (Siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and Siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.

187 results for "Siglec-1/CD169" in Products

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Siglec-1/CD169 Products

Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: Siglecs-1, -2, and -4, and a Siglec-3/CD33-related subgroup (Siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and Siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.

187 results for "Siglec-1/CD169" in Products

ELISA, Flow, Func, ICC/IF, IHC, WB
WB, Flow, CyTOF-ready
Flow, CyTOF-ready

Recombinant Monoclonal Antibody.

WB
WB, Neut
CyTOF-ready, Flow, IHC, IP, WB
Catalog #: FAB5197T
Flow

Recombinant Monoclonal Antibody.

Catalog #: BAF5610
WB
Flow

Recombinant Monoclonal Antibody.

Dual ISH-IHC, IHC
Catalog #: FAB5610T
Flow
Catalog #: FAB5610R
Flow
Catalog #: FAB5610G
Flow
Catalog #: FAB5610V
Flow
Catalog #: FAB5610S
Flow
Catalog #: FAB5610U
Flow
Catalog #: FAB5610N
Flow
Catalog #: FAB5197S
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB5197R
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB5197U
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB5197V
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB5197N
Flow

Recombinant Monoclonal Antibody.

Catalog #: RDC1619
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