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Notch-2 Products

Notch proteins (so named for notches in fly wings) are type I transmembrane glycoproteins involved in specifying cell fates and defining boundaries between different cell types during developmental processes. Notch extracellular domains are large, having 34-36 EGF-like repeats followed by three notch/Lin-12 repeats. Notch proteins interact with transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand binding, a series of cleavage events results in the release of the Notch intracellular domain (NICD), which translocates to the nucleus and initiates transcription of Notch-responsive genes. Thus, Notch acts as both a ligand-binding receptor and a nuclear factor that regulates transcription.

The four mammalian Notch receptors appear to have distinct functions, since they do not compensate for one another in genetic studies. Mutations in Notch receptors also lead to specific developmental disorders. For example, Notch-3 is predominantly expressed in the developing central nervous system of mice. Mutations in Notch-3 in humans cause an autosomal dominant condition called CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). This disorder is characterized by recurrent ischemic strokes at an early age without any underlying vascular risk and progressive dementia.

28 results for "Notch-2" in Products

Notch-2 Products

Notch proteins (so named for notches in fly wings) are type I transmembrane glycoproteins involved in specifying cell fates and defining boundaries between different cell types during developmental processes. Notch extracellular domains are large, having 34-36 EGF-like repeats followed by three notch/Lin-12 repeats. Notch proteins interact with transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand binding, a series of cleavage events results in the release of the Notch intracellular domain (NICD), which translocates to the nucleus and initiates transcription of Notch-responsive genes. Thus, Notch acts as both a ligand-binding receptor and a nuclear factor that regulates transcription.

The four mammalian Notch receptors appear to have distinct functions, since they do not compensate for one another in genetic studies. Mutations in Notch receptors also lead to specific developmental disorders. For example, Notch-3 is predominantly expressed in the developing central nervous system of mice. Mutations in Notch-3 in humans cause an autosomal dominant condition called CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). This disorder is characterized by recurrent ischemic strokes at an early age without any underlying vascular risk and progressive dementia.

28 results for "Notch-2" in Products

Flow, CyTOF-ready
Catalog #: MAB1190
WB
WB, Flow, IHC, Block, CyTOF-ready
WB, IHC
Catalog #: FAB37351G
Flow
Flow
Flow, CyTOF-ready
Catalog #: 1190-NT
Bind
Catalog #: 5196-NT
Bind
Catalog #: 3735-NT
Bind
Catalog #: FAB37351N
Flow
Catalog #: MAB3735
WB

Notch pathway inhibitor; prevents Notch complex assembly

Catalog #: BAF1190
WB, Flow
Catalog #: BAF3735
WB
Catalog #: FAB5196G
Flow
Catalog #: FAB5196R
Flow
Catalog #: FAB37351S
Flow
Catalog #: FAB37351R
Flow
Catalog #: FAB5196V
Flow
Catalog #: FAB37351T
Flow
Catalog #: FAB37351V
Flow
Catalog #: FAB5196U
Flow
Catalog #: FAB5196N
Flow
Catalog #: FAB5196S
Flow
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