CEACAM-5/CD66e Products
CEACAM-5, also known as CEA and CD66e, belongs to the large family of CEACAM and pregnancy specific glycoproteins. CEACAM molecules are either transmembrane or GPI-linked, and are differentially expressed between species. Orthologs of human CEACAM-5 have not been described in other species. CEACAM-5, which is expressed primarily by epithelial cells, consists of an N-terminal Ig like V-set domain followed by six Ig-like C2-set domains and a GPI anchor. CEACAM-5 is synthesized as a 180 kDa, variably glycosylated molecule of which approximately 60% is carbohydrate. CEACAM-5 functions as a calcium independent adhesion molecule through homophilic and heterophilic interactions with CEACAM-1.
CEACAM-5 is restricted to the apical face of intestinal epithelial cells in the adult but is more diffuse during embryonic development and in tumors. This is consistent with a role in the development and maintenance of epithelial architecture. CEACAM-5 is upregulated in a wide variety of human tumors and is a commonly used cancer marker. It promotes tumor cell migration, invasion, adhesion, and metastasis. CEACAM-5 also contributes to tumor formation by maintaining cellular proliferation in the presence of differentiation stimuli, and by blocking apoptosis following loss of ECM anchorage (anoikis).
24 results for "CEACAM-5/CD66e" in Products
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CEACAM-5/CD66e Products
CEACAM-5, also known as CEA and CD66e, belongs to the large family of CEACAM and pregnancy specific glycoproteins. CEACAM molecules are either transmembrane or GPI-linked, and are differentially expressed between species. Orthologs of human CEACAM-5 have not been described in other species. CEACAM-5, which is expressed primarily by epithelial cells, consists of an N-terminal Ig like V-set domain followed by six Ig-like C2-set domains and a GPI anchor. CEACAM-5 is synthesized as a 180 kDa, variably glycosylated molecule of which approximately 60% is carbohydrate. CEACAM-5 functions as a calcium independent adhesion molecule through homophilic and heterophilic interactions with CEACAM-1.
CEACAM-5 is restricted to the apical face of intestinal epithelial cells in the adult but is more diffuse during embryonic development and in tumors. This is consistent with a role in the development and maintenance of epithelial architecture. CEACAM-5 is upregulated in a wide variety of human tumors and is a commonly used cancer marker. It promotes tumor cell migration, invasion, adhesion, and metastasis. CEACAM-5 also contributes to tumor formation by maintaining cellular proliferation in the presence of differentiation stimuli, and by blocking apoptosis following loss of ECM anchorage (anoikis).
24 results for "CEACAM-5/CD66e" in Products
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #487609 |
Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
His-tag
Source : | NS0 |
Accession # : | Q8N4D0 |
Applications : | Binding Activity |
Assay Range : | 31.2 - 2,000 pg/mL |
Applications : | ELISA |
HEK293 Expressed Protein
Source : | HEK293 |
Accession # : | NP_004354.3 |
Applications : | Bioactivity |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #487609 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #487609 |
Applications : | Flow Cytometry |
Biotinylated
Source : | CHO |
Accession # : | NP_004354.3 |
Applications : | Bioactivity |
Biotinylated
Source : | CHO |
Accession # : | NP_004354.3 |
Applications : | Bioactivity |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #487609 |
Applications : | Flow Cytometry |
Source : | NS0 |
Accession # : | Q3UKK2.1 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | Q3UKK2.1 |
Applications : | Bioactivity |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #487609 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #487609 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #487610 |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #487609 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #487609 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #487609 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #487609 |
Applications : | Flow Cytometry |
Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies