Webinar: Go with the Flow: Easy Particle Characterization with Micro-Flow Imaging
Characterization of protein aggregates and other sub-visible particles is essential for monitoring changes in product quality and safety throughout biopharmaceutical development. A unique challenge for particle characterization is the simultaneous presence of protein aggregates and other particle types such as silicone oil micro-droplets, air bubbles, and extrinsic contaminants protein formulations. Traditional techniques providing only size and concentration information cannot distinguish these groups from each other. More comprehensive technologies must therefore be utilized to detect and classify particles into sub-groups based on their unique morphology and particle characteristics.
ProteinSimple's Micro-Flow Imaging (MFI) is ideal for characterization of biopharmaceuticals because it not only measures particle size and count, but also provides quantitative images that allow scientists to sensitively discriminate particle types based on their shape characteristics. In this webinar we will demonstrate how image information provided by MFI can be used to quickly and easily design morphologic filters for routine analysis. We will also review a variety of case studies which describe how to customize and test these filters for accurate particle classification in protein formulations.
Jessica Dermody, Ph.D., Field Application Scientist, ProteinSimple
Chris Heger, Ph.D., Field Application Scientist, ProteinSimple