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Webinar: Easy and Rapid Analysis of Antibody Drug Conjugates and Highly Hydrophobic Proteins

Webinar Summary

Automated methods for charge heterogeneity detection such as imaged capillary isoelectric focusing (icIEF) have been widely adopted by the biopharma industry. These techniques provide rapid high resolution charge variant separation with easy method development and minimal start up time. Imaged cIEF also offers the ability to analyze complex antibody drug conjugates (ADC) and highly hydrophobic peptides and proteins.

In this webinar, Susan Darling will provide an overview of the iCE technology followed by April Xu, Ph.D., Senior Scientist at Pfizer who will present the application of cIEF to enhance process understanding and product characterization for a lysine chemistry-based ADC as well as for monitoring the drug load distribution in final drug product. Scott Mack will review new strategies for analyzing highly hydrophobic proteins such as high density lipoproteins and how to reduce aggregation and hydrophobic interactions during analysis.


April Xu, Ph.D., Sr. Principal Scientist, Pfizer

Susan Darling, Director, Product Management iCE and MFI, ProteinSimple

Scott Mack, Sr. Scientist, ProteinSimple