Webinar: Landscape of Analytical Methods for the Characterization of AAV Full-to-Empty Particle

The complexity and diversity of cell and gene therapies present challenges in standardization of methods and assays for characterization.

Watch the talk by Anthony Blaszczyk to discover how the United States Pharmacopeia (USP) aims to streamline and expedite development of safe and effective therapies through the creation of AAV characterization standards, as well as evaluating multiple methods of full-to-empty ratio analysis.

Key Topics:

• The role of the USP in developing Physical and Documentary Standards to support advanced therapies and emerging technologies
• Comparison of analytical methods for assessing full-to-empty ratio of AAV capsids, including SEC-MALS, spectrophotometry, CE-SDS, and cIEF

Speaker

Anthony Blaszczyk, Ph.D.

Senior Scientist I, USP

Dr. Anthony Blaszczyk is in the Pipeline Development group within USP’s Global Biologics department. At USP, he works with scientific experts and stakeholders to develop new standards to support biopharmaceutical quality assessment and development. Prior to USP, Anthony worked at Catalent Cell and Gene Therapy, where he managed an analytical development team responsible for the development, qualification, and transfer of methods. He obtained his Ph.D. in Biochemistry from Penn State University in 2018.  

This presentation was recorded as part of the Virtual Gene Therapy Symposium on July 19, 2023.