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Simple Western Charge Assays are Enabling Cutting Edge Biomedical Research

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Characterizing the charge heterogeneity of biomolecules can provide profound insight into biological processes. For example, a protein’s charge heterogeneity will change in response to post-translational modifications like phosphorylation, and these changes may not be readily detectable by size-based assays like the traditional Western blot. Simple Western™ Charge assays separate pro- teins by capillary isoelectric focusing based on their pI and can be seamlessly followed up with a highly sensitive immunoassay detec- tion and analysis. Simple Western Charge assays have been used extensively in biomedical research, creating charge heterogeneity fingerprints used to study topics related to cancer, neurological disease, diabetes and more.

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