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Application Brief 1023: Crk-L NanoPro Assay

Application Notes

Application Notes Summary

Crk-like protein (Crk-L) is an adapter protein and phosphotyrosine-containing substrate implicated in transformation by the bcr-abl oncogene and in signaling by cytokines. It has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. Crk-L is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. We show that Crk-L phosphorylation is reduced in response to Imatinib (commonly known as GleevecÆ) treatment in K562 cells.

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