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Advanced CE system for IgG Purity and Heterogeneity Analysis

Scientific Meeting Posters

Scientific Meeting Posters Summary

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Monoclonal antibodies (mAbs) are routinely used as therapeutic and diagnostic products when treating a wide variety of diseases. Due to the importance of these molecules, regulatory agencies have guidelines describing methods to assess product purity necessary for lot release and characterization. CE-SDS is one of the most common techniques used to monitor purity and heterogeneity. iCE3 has been the go-to method for analyzing charge heterogeneity for mAbs. In this poster, we introduce Maurice, the latest member of the iCE platform family, who now gives you high resolution CE-SDS IgG data on top of the exceptional cIEF data you've come to expect. Maurice's CE-SDS application gives you baseline resolution of reduced non-glycosylated and glycosylated IgG heavy chain in just 25 minutes with % Area RSDs less than 4%. A simplified workflow provides unparalleled ease-of-use. Once samples and reagents are prepared, it takes less than 10 minutes to install the cartridge and start your batch. And at the end of your batch, easy clean-up and automatic data analysis by Compass for iCE software lets you quickly start your next batch.

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