(±)-α-Lipoamide

Name: (±)-α-Lipoamide
Brand: Tocris Bioscience
SKU: 7045

Tocris Bioscience, part of Bio-Techne | Catalog # 7045

COA / SDS

Phase-separated condensate modifier; orally bioavailable

Discontinued Product

7045 has been discontinued. View all Buffers, Chelators and Reagents products.

Key Product Details

Description:	Phase-separated condensate modifier; orally bioavailable
Chemical Name:	1,2-Dithiolane-3-pentanamide
Purity:	≥98% (HPLC)
Molecular Weight:	205.33

View Full Technical Details for (±)-α-Lipoamide

Technical Data
Citations

Biological Activity for (±)-α-Lipoamide

(±)-α-Lipoamide is a phase-separated condensate modifier. Reduces propensity of stress granule proteins to aggregate (EC₅₀ = 20 μM in HeLa and iPSCs), and causes FUS stress granule proteins to return to the nucleus in vitro. Stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of ALS patient-derived (FUS mutant) motor neuron axons in culture, and recovers motor defects in D. melanogaster expressing FUS mutants. Suppresses the effects of ALS-associated FUS mutations in vivo in different systems. Orally bioavailable.

Technical Data for (±)-α-Lipoamide

M. Wt	205.33
Formula	C₈H₁₅NOS₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	940-69-2
PubChem ID	863
InChi Key	FCCDDURTIIUXBY-UHFFFAOYSA-N
Smiles	NC(CCCCC1CCSS1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for (±)-α-Lipoamide

References are publications that support the biological activity of the product.

Shen Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 2011 PMID: 21108628

(±)-α-Lipoamide

Tocris Bioscience, part of Bio-Techne | Catalog # 7045

Key Product Details

Biological Activity for (±)-α-Lipoamide

Technical Data for (±)-α-Lipoamide

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for (±)-α-Lipoamide

Product Documents for (±)-α-Lipoamide

COA

Certificate of Analysis

SDS

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