Zopiclone

Name: Zopiclone
Brand: Tocris Bioscience
SKU: 1094

Tocris Bioscience a Bio-Techne Brand

Catalog # 1094

Citations (1)

COA / SDS

Discontinued Product

1094 has been discontinued. View all GABA-A Receptor Benzodiazepines products.

Key Product Details

Description:	Benzodiazepine agonist
Chemical Name:	4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b] pyrazin-5-yl ester
Purity:	≥99% (HPLC)
Molecular Weight:	388.81

View Full Technical Details for Zopiclone

Biological Activity for Zopiclone

A non benzodiazepine BZR agonist, with little difference in affinity for the BZ1 and BZ2 subtypes; however its CNS effects differ from those of other BZR ligands and this may be due to interaction with a different subunit.

Technical Data for Zopiclone

M. Wt	388.81
Formula	C₁₇H₁₇ClN₆O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	43200-80-2
PubChem ID	5735
InChi Key	GBBSUAFBMRNDJC-UHFFFAOYSA-N
Smiles	CN1CCN(CC1)C(=O)OC1N(C(=O)C2=NC=CN=C12)C1=CC=C(Cl)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Zopiclone

References are publications that support the biological activity of the product.

Munakata Heterogeneous distribution of benzodiazepine receptors among rat neostriatal neurones. Br.J.Pharmacol. 1996 PMID: 8762113
Im Potentiation of γ-aminobutyric acid induced chloride currents by various benzodiazepine site agonists with the α1γ2, β2γ2 and α1β2γ2 subtypes of cloned γ-aminobutyric acid type A receptors. Mol.Pharmacol. 1993 PMID: 7901754
Goa and Heel ZopiC.. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy as a hypnotic. Drugs 1986 PMID: 2874974

Citations for Zopiclone (1)

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Citations are publications that use Bio-Techne products. Selected citations for Zopiclone include:

Petroski et al. (2006) Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 subunit-containing GABAA receptors. J Pharmacol Exp Ther. 317:369
PMID: 16399882

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Product Documents for Zopiclone

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.