Zimelidine dihydrochloride

Name: Zimelidine dihydrochloride
Brand: Tocris Bioscience
SKU: 1767

Catalog # 1767 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Selective 5-HT uptake inhibitor

Discontinued Product

1767 has been discontinued. View all 5-HT Transporter Inhibitors products.

Key Product Details

Description:	Selective 5-HT uptake inhibitor
Chemical Name:	(2Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyrindinyl)-2-propen-1-amine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	390.15

View Full Technical Details for Zimelidine dihydrochloride

Technical Data
Citations (1) / Reviews

Biological Activity for Zimelidine dihydrochloride

5-HT re-uptake inhibitor; selective over noradrenalin and dopamine uptake (IC₅₀ values are 0.33, 8.2 and 12 μM respectively). Modulates nociception and induces hyperglycemia in vivo, and is an orally active antidepressant.

Technical Data for Zimelidine dihydrochloride

M. Wt	390.15
Formula	C₁₆H₁₇BrN₂.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	60525-15-7
PubChem ID	6436006
InChi Key	CXGURXWCQYHDIR-ULPVBNQHSA-N
Smiles	Cl[H].Cl[H].CN(C)C\C=C(\C1=CC=C(Br)C=C1)C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Zimelidine dihydrochloride

References are publications that support the biological activity of the product.

Sugimoto Involvement of serotonin in zimelidine-induced hyperglycemia in mice. Biol.Pharm.Bull. 1999 PMID: 10598036
Fasmer Changes in nociception after acute and chronic administration of zimelidine: different effects in the formalin test and substance P behavioural assay. Neuropharmacology 1987 PMID: 2438584
Ogren The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor. Acta Psychiatr.Scand.Suppl. 1981 PMID: 6452789

Citations for Zimelidine dihydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for Zimelidine dihydrochloride include:

Kim et al. (2009) A novel flow cytometric high throughput assay for a systematic study on molecular mechanisms underlying T cell receptor-mediated integrin activation. PLoS One. 4:e6044
PMID: 19557182

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