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Ion Channel Modulators Small Molecule
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Key Product Details

Description: Inhibits pacemaker (If) current
Alternative Names: ICI D7288
Chemical Name: 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride
Purity: ≥99% (HPLC)
Molecular Weight: 292.81

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  • test
    Name: Sergiy Sylantyev
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    We used ZD-7288 to block Ih current in hippocampal pyramidal cells. 10 µM concentration of the compound developed its effect within a characteristic time interval of tens of seconds, making slower decay kinetics of evoked post-synaptic potentials (see illustration). Washout for 15-20 minutes could not restore the control response characteristics, thus suggesting high affinity of the compound.
    No problem with dissolution in water and preparation of 10 mM stock.
    ZD 7288 Serum 1000

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