ZD 7288

Citations are publications that use Bio-Techne products. Selected citations for ZD 7288 include:

• Lopez et al. (2022) Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron. 110:2283
  PMID: 35649415
• Zhang et al. (2018) Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation. Neuron. 98:918
  PMID: 29754751
• Zhao et al. (2018) Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience. 6:138
  PMID: 30240608
• Flynn and Zagotta (2018) Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels. Proc Natl Acad Sci U S A. 115:E8086
  PMID: 30076228
• Harris et al. (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci. 38:8922
  PMID: 30150361
• Collins et al. (2018) Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei. Neuron. 98:366
  PMID: 29628187
• Lezmy (2017) M-current inhibition rapidly induces a unique CK2-dependent plasticity of the axon initial segment. Proc Natl Acad Sci U S A. 114(47):E10234
  PMID: 29109270
• Ghezzi et al. (2016) Electrophysiological characterization of the M-current in rat hypoglossal motoneurons Neuroscience. 340:62
  PMID: 27984184
• Fan et al. (2016) Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(-/-) Mice. Front Cell Neurosci. 10:74
  PMID: 27047338
• Asteriti et al. (2015) A Cambrian origin for vertebrate rods. Elife. 4
  PMID: 26095697
• Kashyap et al. (2015) Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation. Front Cell Neurosci. 2
  PMID: 26709376
• Ferreira et al. (2015) Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala. PLoS One. 9:161
  PMID: 25972785
• Ohno et al. (2015) Hcn1 is a tremorgenic genetic component in a rat model of essential tremor. J Neurosci. 10:e0123529
  PMID: 25970616
• Merino et al. (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. J Neurophysiol. 10:e0132884
  PMID: 26222156
• Williams and Hablitz (2015) Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih. Front Cell Neurosci. 9:89
  PMID: 25852481
• Calejo et al. (2014) Hyperpolarization-activated cyclic nucleotide-gated channels and cAMP-dependent modulation of exocytosis in cultured rat lactotrophs. J Neurosci. 34:15638
  PMID: 25411492
• Dragicevic et al. (2014) Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra DA neurons. Bladder (San Franc). 137:2287
  PMID: 24934288
• Cilz et al. (2014) DA modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels. Cereb Cortex. 24:3195
  PMID: 23843440
• Stark et al. (2013) Inhibition-induced theta resonance in cortical circuits. Neuron. 80:1263
  PMID: 24314731
• Zhang et al. (2013) Molecular mechanisms that drive E2-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area. Am J Physiol Endocrinol Metab. 305:E1384
  PMID: 24105416
• Abbas et al. (2013) Directional summation in non-direction selective retinal ganglion cells. PLoS Comput Biol. 9:e1002969
  PMID: 23516351
• Boehlen et al. (2013) Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells. J Neurophysiol. 109:445
  PMID: 23076110
• Zhang et al. (2013) NE drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors. PLoS One. 8:e66122
  PMID: 23785477
• Yi et al. (2013) Contribution of d1/5 receptor modulation of post-spike/burst afterhyperpolarization to enhance neuronal excitability of layer v pyramidal neurons in prepubertal rat prefrontal cortex. PLoS One. 8:e71880
  PMID: 23977170
• Masi et al. (2013) MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral DA neurons. Br J Pharmacol. 169:130
  PMID: 23323755
• Angelo and Margrie (2012) Population diversity and function of hyperpolarization-activated current in olfactory bulb mitral cells. Sci Rep. 1:50
  PMID: 22355569
• Few et al. (2012) Asynchronous Ca²⁺ current conducted by voltage-gated Ca²⁺ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proc Natl Acad Sci U S A. 109:E452
  PMID: 22308469
• Patel et al. (2012) Frequency-selective exocytosis by ribbon synapses of hair cells in the bullfrog's amphibian papilla. Exp Physiol. 32:13433
  PMID: 23015434
• Ma et al. (2011) High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. J Biomed Sci. 301:H2006
  PMID: 21890694
• Goldberg et al. (2011) Rapid developmental maturation of neocortical FS cell intrinsic excitability. J Neurosci. 21:666
  PMID: 20705896
• Atkinson et al. (2011) Cyclic AMP signaling control of action potential firing rate and molecular circadian pacemaking in the suprachiasmatic nucleus. J Biol Rhythms. 26:210
  PMID: 21628548
• Brummett et al. (2011) Perineural dexmed. added to ropiva. for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current. Anesthesiology. 115:836
  PMID: 21666435
• Chen et al. (2010) Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice. J Neurosci. 30:2611
  PMID: 20164346
• Jung et al. (2010) Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signaling. J Neurosci. 30:6678
  PMID: 20463230
• Gullo et al. (2010) Orchestration of "presto" and "largo" synchrony in up-down activity of cortical networks. Front Neural Circuits. 4:11
  PMID: 20461235
• Chu et al. (2010) Electrophysiological effects of SKF83959 on hippocampal CA1 pyramidal neurons: potential mechanisms for the drug's neuroprotective effects. PLoS One. 5
  PMID: 20957037
• Bal and Baydas (2009) Electrophysiological properties of octopus neurons of the cat cochlear nucleus: an in vitro study. J Assoc Res Otolaryngol. 10:281
  PMID: 19277784
• Ballo and Bucher (2009) Complex intrinsic membrane properties and DA shape spiking activity in a motor axon. J Neurosci. 29:5062
  PMID: 19386902
• Zhang et al. (2009) Developmental expression of a functional TASK-1 2P domain K+ channel in embryonic chick heart. J Neurosci. 16:104
  PMID: 19930646
• Molineux et al. (2008) Ionic factors governing rebound burst phenotype in rat deep cerebellar neurons. Cereb Cortex. 100:2684
  PMID: 18768644
• Russo et al. (2008) Dynamic metabotropic control of intrinsic firing in cerebellar unipolar brush cells. J Neurophysiol. 100:3351
  PMID: 18945818
• Safiulina et al. (2008) Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus. J Physiol. 586:5437
  PMID: 18801845
• Lee and Ishida (2007) Ih without Kir in adult rat retinal ganglion cells. J Neurophysiol. 97:3790
  PMID: 17488978
• Lee and Tepper (2007) A calcium-activated nonselective cation conductance underlies the plateau potential in rat substantia nigra GABAergic neurons. J Neurosci. 27:6531
  PMID: 17567814
• Bender et al. (2007) Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci. 27:4697
  PMID: 17460082
• Angelo et al. (2007) Local and global effects of I(h) distribution in dendrites of mammalian neurons. Am J Physiol Heart Circ Physiol. 27:8643
  PMID: 17687042
• Narushima et al. (2007) Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. PLoS One. 27:496
  PMID: 17234582
• Brager and Johnston (2007) Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons. J Neurosci. 27:13926
  PMID: 18094230
• Zhong and Zucker (2005) cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction. J Neurosci. 25:208
  PMID: 15634783
• Adachi et al. (2005) Noradrenergic modulation of XII motoneuron inspiratory activity does not involve alpha2-receptor inhibition of the Ih current or presynaptic glutamate release. J Appl Physiol (1985). 98:1297
  PMID: 15579572
• Hegg and Lucero (2004) DA reduces odor- and elevated-K(+)-induced calcium responses in mouse olfactory receptor neurons in situ. J Neurophysiol. 91:1492
  PMID: 14657189
• Doan et al. (2004) Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers. Brain. 24:3335
  PMID: 15056713
• Seeburg et al. (2004) Frequency-dependent modulation of retinogeniculate transmission by serotonin. J Neurosci. 24:10950
  PMID: 15574745
• Gill et al. (2004) Characterization of the human HCN1 channel and its inhibition by capsazepine. Br J Pharmacol. 143:411
  PMID: 15351778
• Chan et al. (2004) HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons. J Neurosci. 24:9921
  PMID: 15525777

There are no citations that match your criteria.

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  Name: Sergiy Sylantyev
  Species: Human
  Assay Type: In Vitro
  Cell Line/Tissue: Hippocampus
  We used ZD-7288 to block Ih current in hippocampal pyramidal cells. 10 µM concentration of the compound developed its effect within a characteristic time interval of tens of seconds, making slower decay kinetics of evoked post-synaptic potentials (see illustration). Washout for 15-20 minutes could not restore the control response characteristics, thus suggesting high affinity of the compound.
  No problem with dissolution in water and preparation of 10 mM stock.
  PMID: 32667048
  

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