ZD 7288 is a sino-atrial node function modulator; blocks the hyperpolarization activated cation current I_f (HCN channel). Blocks I_h in central neurons. Increases NMDA-evoked noradrenaline release in rat brain in vitro.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Product Specifications

Molecular Weight

292.81

Formula

C₁₅H₂₁ClN₄

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride

CAS Number

133059-99-1

PubChem ID

123983

InChI Key

DUWKUHWHTPRMAP-UHFFFAOYSA-N

SMILES

[Cl-].CCN(C1=CC=CC=C1)C1=CC(NC)=[N+](C)C(C)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	29.28	100
	DMSO	29.28	100

Preparing Stock Solutions for ZD 7288

The following data is based on the product molecular weight 292.81

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.42 mL	17.08 mL	34.15 mL
5 mM	0.68 mL	3.42 mL	6.83 mL
10 mM	0.34 mL	1.71 mL	3.42 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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Background References

References are publications that support the biological activity of the product.

Klar Ih channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [³H]-noradrenaline release in rat neocortex slices. Naunyn Schmiedebergs Arch.Pharmacol. 2003 PMID: 12690435
Green Pharmacological characterization of the inwardly rectifying current in the smooth muscle cells of the rat bladder. Br.J.Pharmacol. 1996 PMID: 8982495
Harris and Constanti Mechanism of block by ZD7288 of the hyperpolarization-activated inward rectifying current in guinea-pig substantia nigra neurons in vitro. J.Neurophysiol. 1995 PMID: 8747199
BoSmith Inhibitory actions of ZENECA ZD7288 on whole cell hyperpolarization activated inward current (I_f) in guinea-pig dissociated sinoatrial node cells. Br.J.Pharmacol. 1993 PMID: 7693281

ZD 7288

Tocris Bioscience, part of Bio-Techne | Catalog # 1000

Key Product Details

Description

Alternative Names

View all HCN Channel Blockers »

Product Description