WAY 200070

Name: WAY 200070
Brand: Tocris Bioscience
SKU: 3366

Tocris Bioscience a Bio-Techne Brand

Catalog # 3366

Citations (4)

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Key Product Details

Description:	Selective ERβ agonist
Chemical Name:	7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
Purity:	≥98% (HPLC)
Molecular Weight:	306.11

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Biological Activity for WAY 200070

WAY 200070 is a selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC₅₀ values are 2 and 155 nM for ERβ and ERα respectively). Displays antianxiolytic and antidepressive effects in vivo.

Compound Libraries for WAY 200070

WAY 200070 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WAY 200070

M. Wt	306.11
Formula	C₁₃H₈BrNO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	440122-66-7
PubChem ID	9861330
InChi Key	IVFWABSHZFOMIG-UHFFFAOYSA-N
Smiles	BrC1=C2C(N=C(C3=CC=C(O)C=C3)O2)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WAY 200070

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.61	100
	ethanol	15.31	50

Preparing Stock Solutions for WAY 200070

The following data is based on the product molecular weight 306.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.27 mL	16.33 mL	32.67 mL
5 mM	0.65 mL	3.27 mL	6.53 mL
10 mM	0.33 mL	1.63 mL	3.27 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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References for WAY 200070

References are publications that support the biological activity of the product.

Hughes WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology 2008 PMID: 18423777
Clipperton Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology 2008 PMID: 18004284
Malamas Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 2004 PMID: 15456246

Citations for WAY 200070 (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for WAY 200070 include:

Oberlander (2016) 17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females. J Neurosci. 36:2677
PMID: 26937008
Sellers et al. (2015) Rapid modulation of synaptogenesis and spinogenesis by 17β-OE in primary cortical neurons. Front Cell Neurosci. 9:137
PMID: 25926772
Alonso-Magdalena et al. (2013) Antidiabetic actions of an estrogen receptor β selective agonist. PLoS One. 62:2015
PMID: 23349481
Cao et al. (2012) Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat. J Pain. 13:685
PMID: 22698981

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