VU 0361737

Name: VU 0361737
Brand: Tocris Bioscience
SKU: 3707

Tocris Bioscience, part of Bio-Techne | Catalog # 3707

Citations (29)

COA / SDS

Selective positive allosteric modulator of mGlu4 receptors

Discontinued Product

3707 has been discontinued. View all Group III mGluR Modulators products.

Key Product Details

Description:	Selective positive allosteric modulator of mGlu₄ receptors
Chemical Name:	N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	262.69

View Full Technical Details for VU 0361737

Technical Data
Citations

Biological Activity for VU 0361737

VU 0361737 is a selective positive allosteric modulator at mGlu₄ receptors (EC₅₀ values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu₁, mGlu₂, mGlu₃, mGlu₆ and mGlu₇ receptors and displays weak activity at mGlu₅ and mGlu₈ receptors. Brain penetrant.

Technical Data for VU 0361737

M. Wt	262.69
Formula	C₁₃H₁₁ClN₂O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1161205-04-4
PubChem ID	44191096
InChi Key	ARYUXFNGXHNNDM-UHFFFAOYSA-N
Smiles	ClC1=C(OC)C=C(NC(C2=NC=CC=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VU 0361737

References are publications that support the biological activity of the product.

Engers Discovery, synthesis, and structure-activity relationship development of a series of N-(4-Acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats. J.Med.Chem. 2011 PMID: 21247167
Engers Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J.Med.Chem. 2009 PMID: 19469556

VU 0361737

Tocris Bioscience, part of Bio-Techne | Catalog # 3707

Key Product Details

Biological Activity for VU 0361737

Technical Data for VU 0361737

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for VU 0361737

Product Documents for VU 0361737

COA

Certificate of Analysis

SDS

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